Lightlab Imaging, Inc.

Joel M Friedman

Joseph M Schmitt

Amr Medhat Elbasiony

Christopher Petroff

Christopher L Petersen

Christopher E Griffin

Stephen McCartin

James G Peterson

Sonal Ambwani

Satish Kaveti

Amr Elbasiony

Neil Judell

Robert Steinbrecher

Ashley Netravali

Lingfa Yang

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimate blood flow rate, a number of clinically significant physiological parameters are then determine and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

Blood vessel lumen morphology and minimum lumen area measurements data collection by intravascular imaging systems for stenosis or stent planning

A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

Lumen morphology and vascular resistance measurements data collection systems apparatus and methods

Aspects of the disclosure relate to the identification of when a blood vessel has been sufficiently cleared of blood so as to capture intravascular images of the vessel wall. The disclosed systems and methods allow for the identification of an initial and a final blood clearing based on the identification of edges within scanlines of a plurality of image frames. The edges of a plurality of scanlines may be analyzed to determine an average edge offset for each image frame, and the average edge offsets for a plurality of image frames may be averaged over various time-windows, so as to determine when the initial and final blood clearing events have occurred. Once a final blood clearing event has been identified, the disclosed system may automatically initiate a catheter pullback procedure, so as to capture intravascular images over a length of the vessel that has been sufficiently cleared of blood.

Systems and methods for an automatic pullback trigger

The disclosure relates, in part, to computer-based visualization of stent position within a blood vessel. A stent can be visualized using intravascular data and subsequently displayed as stent struts or portions of a stent as a part of a one or more graphic user interface(s) (GUI). In one embodiment, the method includes steps to distinguish stented region(s) from background noise using an amalgamation of angular stent strut information for a given neighborhood of frames. The GUI can include views of a blood vessel generated using distance measurements and demarcating the actual stented region(s), which provides visualization of the stented region. The disclosure also relates to display of intravascular diagnostic information such as indicators. An indicator can be generated and displayed with images generated using an intravascular data collection system. The indicators can include one or more viewable graphical elements suitable for indicating diagnostic information such as stent information.

Stent detection methods and imaging system interfaces

In part, the invention relates to systems and methods of calibrating a plurality of frames generated with respect to a blood vessel as a result of a pullback of an intravascular imaging probe being pullback through the vessel. A calibration feature disposed in the frames that changes between a subset of the frames can be used to perform calibration. Calibration can be performed post-pullback. Various filters and image processing techniques can be used to identify one or more feature in the frames including, without limitation, a calibration feature, a guidewire, a side branch, a stent strut, a lumen of the blood vessel, and other features. The feature can be displayed using a graphic user interface.

Calibration and image processing devices, methods, and systems

Intravascular imaging system interfaces and stent detection methods

Optical coherence tomography lumen morphology and vascular resistance measurements methods for blood vessel evaluations

Growing community of inventors

Andover, MA, United States of America

Joel M Friedman