Dana-farber-cancer Institute Inc.

Other

Joel L Schwartz

Harvey I Cantor

Roberto M Patarca

Gordon James Freeman

Christopher Sikorski

Gerald Shklar

Complexes of .beta. carotene with cyclodextrin are described, having reduced color intensity and a shift of color to tones more neutral than the deep red of uncomplexed .beta. carotene. When these complexes are added to topical compositions such as typical skin cream bases in amounts up to 1.0% .beta. carotene w/v, the result is a cream having a pinkish to beige color which is cosmetically acceptable, as opposed to the mustard orange to red color seen in creams containing like amounts of uncomplexed .beta. carotene.

Process for preparing decolorized carotenoid-cyclodextrin complexes

The present invention relates to genes and their encoded proteins which induce immunological effector cell activation and chemattraction. The proteins of the invention attract subsets of immunological effector cells and stimulate them to express their specialized effector cell functions. Such proteins, termed Ap-1 proteins, are expressed by lymphoid cells, and bind to effector cells such as macrophages and mast cells. In particular, the Ap

Nucleic Acids Encoding proteins which induce immunological effector cell

The present invention relates to genes and their encoded proteins which induce immunological effector cell activation and chemattraction. The proteins of the invention attract subsets of immunological effector cells and stimulate them to express their specialized effector cell functions. Such proteins, termed Ap-1 proteins, are expressed by lymphoid cells, and bind to effector cells such as macrophages and mast cells. In particular, the Ap-1 proteins induce macrophage phagocytosis, expression of class II major histocompatibility molecules, cytotoxicity, and migration, and induce hematopoietic progenitor cell differentiation. The Ap-1 molecules can be of value in the therapy or diagnosis of inflammatory or immune disorders, or neoplasia.

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Newton Centre, MA, United States of America

Joel L Schwartz