The State University of New York

University of Texas System

Institute for Systems Biology

Joel Haskin Saltz

Tahsin M Kurc

Tianhao Zhao

Wei Zhu

Yi Gao

Sampurna Shrestha

Si Wen

Ashish Sharma

Ilya Shmulevich

Arvind Rao

John Van Arnam

Le Hou

Pankaj Singh

Vu Nguyen

Alexander Lazar

Rajarsi Gupta

Rebecca Batiste

Dimitrios Samaras

Vesteinn Thorsson

A method of testing an impedance-sensitive system with a switching device, wherein the method comprises: switching the disconnecting device into the on-state configured to permit transmission of energy via the coil; implementing a first measurement with the impedance-sensitive system; switching the disconnecting device into the off-state configured to permit damping of the external positioning signal that couples into the coil so as to reduce the undesirable oscillations of the coil; implementing a second measurement with the impedance-sensitive system; performing a comparison of the first measurement and the second measurement; performing a verification of the comparison with a target specification; and displaying a correct function and/or a malfunction depending on the verification.

System and method associated with predicting segmentation quality of objects in analysis of copious image data

A system associated with predicting segmentation quality of segmented objects implemented in the analysis of copious image data is disclosed. The system receives a collection of image data related to a particular type of data. The image data is segmented into segmented data portions based on an object associated with the collection of image data. Regions of interest associated with the segmented data portions are determined. The quality of segmentation of the segmented data portions is determined for respective classification of the regions of interest. A classification label is assigned to the regions of interest. Regions of interest are partitioned into sub-regions. Features associated with the sub-regions of the segmented data portions are determined. A training dataset is generated based on the determined features associated with the sub-regions in order to train a classification model based on a predetermined threshold value. Test images are received to iteratively classify segmented data portions based on an object associated with the test images, using the trained classification model. The segmentation quality of segmented objects in the test images is predicted based on the trained classification model. A corresponding method and computer-readable device are also disclosed.

A system associated with quantifying a density level of tumor-infiltrating lymphocytes, based on prediction of reconstructed TIL information associated with tumoral tissue image data during pathology analysis of the tissue image data is disclosed. The system receives digitized diagnostic and stained whole-slide image data related to tissue of a particular type of tumoral data. Defined are regions of interest that represents a portion of, or a full image of the whole-slide image data. The image data is encoded into segmented data portions based on convolutional autoencoding of objects associated with the collection of image data. The density of tumor-infiltrating lymphocytes is determined of bounded segmented data portions for respective classification of the regions of interest. A classification label is assigned to the regions of interest. It is determined whether an assigned classification label is above a pre-determined threshold probability value of lymphocyte infiltrated. The threshold probability value is adjusted in order to re-assign the classification label to the regions of interest based on a varied sensitivity level of density of lymphocyte infiltrated. A trained classification model is generated based on the re-assigned classification labels to the regions of interest associated with segmented data portions using the adjusted threshold probability value. An unlabeled image data set is received to iteratively classify the segmented data portions based on a lymphocyte density level associated with portions of the unlabeled image data set, using the trained classification model. Tumor-infiltrating lymphocyte representations are generated based on prediction of TIL information associated with classified segmented data portions. A refined TIL representation based on prediction of the TIL representations is generated using the adjusted threshold probability value associated with the classified segmented data portions. A corresponding method and computer-readable device are also disclosed.

System and method to quantify tumor-infiltrating lymphocytes (TILs) for clinical pathology analysis based on prediction, spatial analysis, molecular correlation, and reconstruction of TIL information identified in digitized tissue images

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Manhasset, NY, United States of America

Joel Haskin Saltz