Other

Elorac, Inc.

Winston Laboratories, Inc.

Hyland UK Operations Limited

Soft Sheen Products, Inc.

Genderm Corporation

Gideon Pharmaceuticals, Inc.

Galenpharma, Inc.

Dermall Limited

Jaye-boern Laboratories, Inc.

Sirius Laboratories, Inc.

Amethyst Investment Group, Inc.

Exopharma, Inc.

Cisco Limited Partnership

Dermalogical Enterprises, Ltd.

Joel E Bernstein

John Newton

Clarence J Endicott

Michael Suzuki

Kenneth M Verburg

A system and method for providing fine-grained access control in a search engine. Access control predicates associated with a search query, including fixed-width and/or variable-width tokens, are received from the search engine, and are formatted in a machine-readable binary format to generate a single byte array. A pre-sorted memory index structure associated with the single byte array is generated, by sorting the access control predicates according to their token width. The pre-sorted memory index structure is merge joined with an uninverted terms index that includes a sorted list of all terms in a field associated with the search query, and a document index mapping the document identifier (ID) to a term ordinal for a specific field.

Scalable fine grained access control within a search engine

A method for real-time analytical queries of a documents store is provided. The method includes receiving a query and an access control list associated with a user, the query requesting content managed by a content management system. The method further includes generating an execution plan based on the query and the access control list. The method further includes constraining, based on the execution plan, possible results returned from the query using a content index of a plurality of content items maintained in a repository of the content management system. The constraining includes limiting the at least one processor from adding a content item of the plurality of content items to a permissions-filtered results set based on the access control list identifying the user as not having permission to access the content item. The method further includes aggregating the permissions-filtered results set and returning the aggregated permissions-filtered results set.

Real-time analytical queries of a document store

A system and method for providing fine-grained access control in a search engine. Access control predicates associated with a search query, including fixed-width and/or variable-width tokens, are received from the search engine, and are formatted in a machine-readable binary format to generate a single byte array. A pre-sorted memory index structure associated with the single byte array is generated, by sorting the access control predicates according to their token width. The pre-sorted memory index structure is merge joined with an uninverted terms index that includes a sorted list of all terms in a field associated with the search query, and a document index mapping each document identifier (ID) to a term ordinal for a specific field.

Improved methods and compositions are disclosed for treating dry eye by administering intranasally a therapeutically effective amount of a capsaicinoid compound embedded in multiple layers of solid lamellar crystals of monoglycerides to patients with deficient tear production. The lipophilic capsaicinoid drug is embedded in multiple layers of solid lamellar crystals of monoglycerides, and these crystals are incorporated into pharmaceutically acceptable vehicles comprised of solutions, suspensions, foams, creams, ointments, and gels. The resulting formulations of the capsaicinoid are suitable for application to the nasal mucosa or skin and are more stable, less irritating to skin and mucous membranes, and provide increased and more controlled release of the capsaicinoid compound.

Method for alleviating keratoconjunctivitis sicca

Improved methods and compositions are disclosed for treating dry eye by administering intranasally a therapeutically effective amount of a capsaicinoid compound embedded in multiple layers of solid lamellar crystals of monoglycerides to patients with deficient tear production. The lipophilic capsaicinoid drug is embedded in multiple layers of solid lamellar crystals of monoglycerides, and these crystals are incorporated into pharmaceutically acceptable vehicles comprised of solutions, suspensions, foams, creams, ointments, and gels. The resulting formulations of the capsaicinoid are more stable, less irritating to skin and mucous membranes, and provide increased and more controlled release of the capsaicinoid compound.

A method and composition for treating chronic inflammatory disorders comprising a pharmaceutically acceptable carrier suitable for oral administration or injection and containing a therapeutic amount of a complex of dietary supplement ingredients comprising nicotinamide, quercetin, curcumin, EPA, DHA, hesperetin and glychrrhizin.

Method and compositions for treating chronic inflammatory disorders

Pharmaceutical compositions of hepatotoxic compounds are provided in which the hepatotoxicity of the compounds is mitigated by including quantities of nicotinamide and methionine in the composition. Folic acid also can be included to further mitigate the hepatotoxic effects. The hepatotoxic compounds can include acetaminophen, methotrexate, atorvastatin, simvastatin, niacin, flucanozole, divalproex sodium, and valproic acid.

Compositions with reduced hepatotoxicity

Methods and compositions are described for the treatment of very severe acne vulgaris, including nodulocystic acne and conglobate acne. Compounds which inhibit either or both type 1 and type 2 isoforms of steroid 5&#x3b1;-reductase are administered daily in either oral or topical formulations to patients suffering from severe forms of acne vulgaris. Very high dosages of such compounds can effectively be administered oral just once a week and be successful.

Method and composition for treating nodulocystic and conglobate acne vulgaris

Therapeutic compositions of doxepin and having a preponderance of the cis doxepin isomer over the trans doxepin isomer provide therapeutic effects for affective, painful, or allergic disorders without the sedative effects commonly experienced with compositions having a preponderance of the trans doxepin isomer.

Compositions and method for treating affective, painful or allergic disorders

A method of treating inflammatory acne vulgaris or inflammatory acne rosacea comprises the topical application of a formulation incorporating carbamide peroxide in a pharmaceutically acceptable vehicle. Inflammatory acneform lesions that can be successfully treat with the inventive method include erythematous papules, pustules, nodules, and cysts. Suitable pharmaceutical vehicles for the topical application of carbamide peroxide include creams, gels, lotions, solutions, suspensions, and ointments.

Method of treating inflammatory acne vulgaris and rosacea with carbamide peroxide

A method of providing relatively long term diminishment or prevention of painful disorders comprises the topical or intranasal administration of civamide or one of its salts in an amount of about 0.001% to 1.0% by weight in a pharmaceutically acceptable vehicle over a relatively short term treatment period to provide unexpectedly long-lasting pain relief.

Method for providing long-lasting pain diminishment through topical or intranasal administration of civamide

An article for use in the treatment of acne vulgaris comprises a cloth pledgette impregnated with a composition comprising benzoyl peroxide and an amount of acetone sufficient to solubilize the benzoyl peroxide. In a preferred embodiment, the article is packaged in an individual pouch. A method of manufacturing the article is disclosed.

Method of treating acne vulgaris and composition

A method for treating painful fibromuscular disorders comprising topical application to the skin of a therapeutically effective amount of a tricyclic antidepressant compound in a pharmaceutically acceptable vehicle.

Growing community of inventors

Deerfield, IL, United States of America

Joel E Bernstein