Regeneron Pharmaceuticals, Inc.

Joel C Reinhardt

Lynn Macdonald

Joel H Martin

Marc R Morra

Richard Torres

Paul Tiseo

Methods are disclosed for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-human NGF antibody, or antigen-binding fragment thereof, wherein at least one symptom associated with osteoarthritis is prevented, ameliorated or improved.

Method of treating osteoarthritis with an antibody to NGF

A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with Kof 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

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Mount Kisco, NY, United States of America

Joel C Reinhardt