Serono Genetics Institute S.a.

University of Tennessee Research Foundation

Genset S.a.

Merck Serono Biodevelopment

Serono Genetica Institute S.a.

Joel A Peek

Leah Diane Fletcher

Robert J Zagursky

Benjamin J Metcalf

Susan K Hoiseth

Banumathi Sankaran

Rémy Griffais

Ronald K Taylor

Robert John Zagursky

The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of thegenome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosinginfection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular, infections.

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Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection

The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular infections.

Chlamydia pneumoniae polynucleotides and uses thereof

A method to inhibit the function of a class of bacterial periplasmic oxidoreductase enzymes, exemplified by TcpG of,, DsbA of,, and Por of,, is disclosed. A screening method to determine whether a chemical inhibits the function of the oxidoreductase enzymes is disclosed. Mutant bacteria lacking the ability to produce a functional periplasmic oxidoreductase and a cloned expression vector overproducing TcpG are also disclosed.

Method for producing a recombinant protein

A screening method to determine whether a chemical inhibits the function of a class of bacterial periplasmic oxidoreductase enzymes, exemplified by TcpG of Vibrio cholerae, DsbA E. coli, and Por of Haemophilus influenzae, id disclosed.

Methods for determining effects of a compound on the activity of

A method for increasing the yield of recombinant non-bacterial or bacterial gene products from bacteria comprising inserting a non-bacterial or bacterial gene into the genetic material of the bacteria whereby the inserted gene is co-expressed with a desired recombinant non-bacterial or bacterial gene product and aids the arrangement of the gene product into the proper final conformation. The non-bacterial or bacterial gene for insertion into the genetic material is also disclosed.

TcpG gene of vibrio cholerae

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Pittsford, NY, United States of America

Joel A Peek