Roche Palo Alto LLC

F. Hoffmann-la Roche Ag

Joe Timothy Bamberg

David Bernard Smith

Michael Soth

Johannes Cornelius Hermann

Remy Lemoine

Yan Lou

Timothy D Owens

Todd Richard Elworthy

Rama K Kondru

Robert Than Hendricks

Tobias Gabriel

Hanbiao Yang

Daisy Joe DuBois

Counde O'Yang

Alam Jahangir

Shu-Hai Zhao

Wylie Solang Palmer

Calvin Wesley Yee

Nancy Elisabeth Krauss

Daisy Joe Du Bois

Taraneh Mirzadegan

Jaehyeon Park

Meng Sui

Mark Bartlett

The present invention relates to the use of novel pyrrolopyrazinyl urea derivatives of Formula I, wherein the variables R, R, R, R, and Rare defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.

Pyrrolopyrazinyl urea kinase inhibitors

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Pyrrolopyrazine kinase inhibitors

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Compounds of formula I or formula II: or pharmaceutically acceptable salts thereof, wherein m, n, p, Ar R, R, R, and Rare as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds.

Indole and benzofuran 2-carboxamide derivatives and uses thereof

The present invention provides a compound of the Formula: a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, wherein m, n, Ar, R, R, R, R, and Rare those defined herein. The present invention also provides methods for using and preparing compounds of Formula I.

Cathepsin K inhibitors

Indole nitriles

Growing community of inventors

East Palo Alto, CA, United States of America

Joe Timothy Bamberg