Smithkline Corporation

Joe R Wardell, Jr

Carl Kaiser

L Martin Brenner

Timothy Yu-Wen Jen

4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon internal administration. The active ingredients are prepared by cyclizing N-(2-substituted benzyl)-1-(3,4-dimethoxyphenyl)-aminoethanol using either a Lewis acid or an acid cyclizing agent followed by demethylation at the 3,4-dimethoxyphenyl moiety.

Renal dilating methods and compositions using

.alpha.-Aminoalkyl-3-(1,2-dihydroxyethyl)-4-hydroxy-benzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are disclosed.

.alpha.-AMINOALKYL-3-(1,2-DIHYDROXYETHYL)-4-HYDROXY-BENZYL ALCOHOLS

3-Substituted-3-hydroxyphenyl-2-piperidylcarbinols are prepared. These compounds are .beta.-adrenergic stimulants and are useful in particular as bronchodilators.

Growing community of inventors

Willingboro, NJ, United States of America

Joe R Wardell, Jr