Tempest Therapeutics, Inc.

Joe Fred Nagamizo

Yalda Mostofi Bravo

Austin Chih-Yu Chen

Renata Marcella Oballa

Robert Gomez

David Andrew Powell

Jinyue Ding

Tao Sheng

Heather Lam

Jason David Burch

Compounds, compositions and methods are provided for modulating the activity of EPand EPreceptors, and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to the activity of EPand EPreceptors. In certain embodiments, the compounds are antagonists of both the EPand EPreceptors.

Bicyclic carboxamides and methods of use thereof

The present disclosure is directed to novel compounds of Formula I and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of cancer, including glioblastoma, bone cancer, head and neck cancer, melanoma, basal cell carcinoma, squamous cell carcinoma, adenocarcinoma, oral cancer, esophageal cancer, gastric cancer, intestinal cancer, colon cancer, bladder cancer, hepatocellular carcinoma, renal cell carcinoma, pancreatic cancer, ovarian cancer, cervical cancer, lung cancer, breast cancer, and prostate cancer. The compounds of the disclosure are selective antagonists of the EP4 receptor and useful treatment of various diseases that may be ameliorated with blockade of PGE2-mediated signaling.

Bicyclic compounds and their use in the treatment of cancer

The present disclosure is directed to novel compounds of Formula I and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g. controlling, alleviating, or slowing the progression of) of cancer, including glioblastoma, bone cancer, head and neck cancer, melanoma, basal cell carcinoma, squamous cell carcinoma, adenocarcinoma, oral cancer, esophageal cancer, gastric cancer, intestinal cancer, colon cancer, bladder cancer, hepatocellular carcinoma, renal cell carcinoma, pancreatic cancer, ovarian cancer, cervical cancer, lung cancer, breast cancer, and prostate cancer. The compounds of the disclosure are selective antagonists of the EP4 receptor and useful treatment of various diseases that may be ameliorated with blockade of PGE2-mediated signaling.

Growing community of inventors

San Diego, CA, United States of America

Joe Fred Nagamizo