Closure Medical Corporation

Joe B Barefoot

Keith R D'Alessio

Upvan Narang

Ibraheem T Badejo

Daniel L Hedgpeth

Anthony S Voiers

Gabriel N Szabo

Andres Rivera

Julian A Quintero

Jeffrey G Clark

Jerry Y Jonn

William M Cotter

J Christopher Marmo

John S Bobo

Lawrence H Mainwaring

Anthony J Sherbondy

Scott Marc Cannizaro

Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.

Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto

A disposable applicator includes a generally tubular applicator body having a closed proximal end and an open distal end and a frangible vial inside. The proximal end is covered by a drying swab while the distal end is covered by an applicator swab that is in open communication with the interior of the applicator body. Within the applicator body is a frangible vial containing a biomedically useful liquid composition, such as an &agr;-cyanoacrylate adhesive, a medicament, or both. The applicator is useful for applying liquid compositions to target sites such as tissue, particularly sites of topical pathology, such as stomatitis lesions.

Applicator for dispensable liquids

An applicator for dispensing compositions includes a crushable ampoule covered with a barrier material that serves as a protective barrier. The applicator can also include a body made of a flexible material that holds at least one crushable ampoule. The protective barrier protects the user's fingers from puncture by shards created during breakage of the crushable ampoule.

Applicator with protective barrier

A composition comprising a polymerizable adhesive monomer is applied over a biologically active initiator or accelerator for polymerization of the monomer. The biologically active initiator or accelerator is a medicament that provides a desired medical or therapeutic activity as well as enhancing polymerization of the adhesive.

Method of applying an adhesive composition over a bioactive polymerization initiator or accelerator

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Raleigh, NC, United States of America

Joe B Barefoot