Venatorx Pharmaceuticals, Inc.

Jodie Hamrick

Christopher J Burns

Denis Daigle

Robert E Lee Trout

Randy W Jackson

Steven Armen Boyd

Daniel C Pevear

Bin Liu

Daniel McGarry

Eugen F Mesaros

Guo-Hua Chu

Stephen M Condon

Allison L Zulli

Cullen L Myers

Matthew Lucas

Jiangchao Yao

Zhenrong Xu

Timothy Henkel

Luigi Xerri

Robert E Trout

Daniel Mcgarry

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Penicillin-binding protein inhibitors

The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

Broad-spectrum carbapenems

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Beta-lactamase inhibitors

Growing community of inventors

New Holland, PA, United States of America

Jodie Hamrick