The United States of America As Represented by the Secretary of

University of Iowa Research Foundation

Biotechnology Research and Development Corporation

Jodi A Laakso

Patrick F Dowd

Donald T Wicklow

James B Gloer

Mark R TePaske

Gail M Staub

Sulpinine C, secopenitrem B and 10-oxo-11,33-dihydropenitrem B indole compounds have been isolated from the sclerotia of the fungi Aspergillus sulphureus. Aflatrem B has been isolated from the sclerotia of the fungi Aspergillus flavus, and 14-hydroxypaspalinine and 14-(N,N-dimethylvalyloxy)paspalinine have been isolated from the sclerotia of the fungi Aspergillus nomius. The indole compounds are effective for controlling Coleopteran and Lepidopteran insects.

Indole antiinsectan metabolites

Indole compounds named 'sulphinine' and 'secopenitrem' have been isolated from the sclerotia of from fungi Aspergillus sulphureus. An indole compound named 'aflatrem B' has been isolated from the sclerotia of the fungi Aspergillus flavus. The compounds are effective for controlling Coleopteran and Lepidopteran insects.

Sulpinine, secopenitrem B and aflatrem B antiinsectan metabolites

Indole diterpene compounds named 'radarin' have been isolated from the sclerotia of the fungus Aspergillus sulphureus. The radarins are effective for controlling Lepidopteran insects, and have the structures: ##STR1## wherein the compound formed when R is a hydroxyl group is designated radarin A and the compound formed when R is a hydrogen atom is designated radarin C; and ##STR2## wherein the compound formed when R is a hydrogen atom is designated radarin D and the compound formed when R is a hydroxyl group is designated radarin B.

Radarin antiinsectan metabolites

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Jodi A Laakso