Cognis IP Management Gmbh

Jochen Seifert

Bernhard Gutsche

Ulrich Schörken

Carolin Meyer

Jean Rigal

Horst Josten

Albert Strube

Claudia Scholz

Christophe Carite

Christophe Sicre

David Melchior

Valerie Eychenne

Christiane Richard-Elsner

The disclosed invention relates to the use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultivation and, more particularly, as a substitute for foetal bovine serum. In one aspect, the esters comprise more than 50 mol-% of physiologically active fatty acids containing 16 to 24 carbon atoms and 2 to 5 double bonds as the acid component and a lower Calcohol, preferably ethanol, or a sterol as ester component. In another aspect, the esters comprise a transesterification product of natural or synthetic oils or a mixture of such oils having greater than 50 mol-% of unsaturated, physiologically active fatty acids, based on the acyl group, and a lower Calcohol or a sterol. In a further aspect, the esters are used together with sterols, phospholipids and/or vegetable proteins or are liposomally encapsulated.

Use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultures

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Muehltal, Germany

Jochen Seifert