Sanofi-a Ventis Deutschland Gmbh

Aventis Pharma Deutschland, Gmbh

Jochen Hachtel

Bernd Neises

Wolfgang Fiedler

Wilfried Schwab

Wolfgang Holla

Frank Zocher

Stephane Mutti

Roland Utz

Bernd Junker

Berndt Kulitzscher

Thomas Stuedemann

Andreas Burgard

Christophe Salagnad

Christoph Tappertzhofen

Claus-Jügen Maier

Rolf Hoerlein

Martin Zahn

The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.

Method for the production of diarylcycloalkyl derivatives

The invention relates to a process for the preparation of a compound of the general formula (I) in which  

Process for the preparation of substituted 2-(phenoxymethyl)benzoic acids

Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids

A process is described for producing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamide, in which a phenyl-substituted 2-cyano-N-(phenyl)acetamide is reacted in the presence of a base, acetic anhydride and at least one solvent, and the resultant 2-cyano-3-hydroxy-N-(phenyl-derivative)but-2-enamide is crystallized by acidification.

Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides

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Frankfurt-am-Main, Germany

Jochen Hachtel