Roche Nimblegen, Inc.

Jochen Bühler

Klaus-Peter Stengele

Todd Richmond

Matthew Rodesch

Tom Albert

The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cmwhere the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.

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Waldkraiburg, Germany

Jochen Bühler