Berg LLC

University of Miami

Other

Jjr&d, LLC

Bpgbio, Inc.

Joaquin J Jimenez

Niven Rajin Narain

John Patrick McCook

Rangaprasad Sarangarajan

Adel A Yunis

John Patrick Mccook

Thomas Mitchell Gray

John P McCook

Yeon S Ahn

Wenche Jy

Eugene Ahn

Lawrence L Horstmann

Compositions and methods for treating cancer, particularly leukemia, using a cytotoxic composition comprising monocytes activated by β-glucan. The monocytes are preferably incubated with the β-glucan and then processed to extract particles, such as microvesicles and exosomes from the treated monocytes to produce the cytotoxic composition. Preferably the cytotoxic composition comprises at least 50% exosomes having a size of 150 nm or less that are activated with β-glucan. Zymosan is the preferred β-glucan. The cytotoxic composition has an apoptosis effect. When a subject having cancer is treated according to preferred embodiments, the cytotoxic composition preferably induces a cytokine response in the subject's immune system. The combination of the cytotoxic composition and cytokine response are synergistic.

Cancer cytotoxic exosome formulations and methods for use in treating cancer

Compositions and methods for treating alopecia, particularly chemotherapy-induced alopecia, using oxidizers or oxidants, pro-oxidant compounds, or activators of P53. Compositions comprising organic peroxides such as, cumene hydroperoxide, tert-Butyl hydroperoxide (t-BHP), hydrogen peroxide, benzoyl peroxide are preferred. Compositions may be applied subcutaneously, percutaneously, or topically. Most preferably, the compositions are applied to a treatment area prior to a round of chemotherapy to prevent or reduce hair loss in the treatment area.

Method of preventing and treating chemotherapy-induced alopecia

The invention provides methods and compositions for treatment of a subject with a central nervous system (CNS) tumor comprising administration of Coenzyme Q10 (CoQ10), particularly when the subject exhibits at least one CNS abnormality as a result of the tumor.

Method of treating or preventing tumors of the central nervous system

The invention provides methods and pharmaceutical compositions for preventing or treating alopecia, such as chemotherapy-induced alopecia (CIA). The pharmaceutical compositions of the invention comprises an effective amount of a vitamin D compound in a formulation that topically delivers the vitamin D compound to the epidermis layer but substantially avoids the dermis layer. In chemotherapy patients, the pharmaceutical compositions of the invention can be administered either before or concurrent with the chemotherapy medication.

Vitamin D3 and analogs thereof for treating alopecia

The invention provides regimens and methods for the treatment of cancer comprising continuous infusion of coenzyme Q10. The coenzyme Q10 may be administered as a monotherapy, or in combination with an additional agent, such as an anticancer agent, a chemotherapeutic agent, or an anti-angiogenic agent. The coenzyme Q10 may be administered at two or more different rates.

Methods of treatment of cancer by continuous infusion of coenzyme Q10

Compositions comprising membrane-derived and synthetic microparticles that induce platelet aggregation and are useful for treating bleeding disorders, particularly those involving platelet dysfunction. Microparticles include endothelial derived microparticles (EMP), platelet derived microparticles (PMP), erythrocyte derived microparticles (RMP), and synthetic microparticles (SMP), and are used to treat disorders such as thrombocytopenia caused by chemotherapy.

Cell-derived microparticles as hemostatic agents for control of hemorrhage and treatment of bleeding disorders

The cooler is a standard piece of recreational equipment. This device combines the utility of a cooler with an umbrella, a radio, speakers, and a bottle opener. Because this device combines all three functions in one device the consumer is not required to purchase or carry each item separately. A handle and wheels have been installed on this device to allow the user an easy way to transport this device.

Cooler and umbrella assembly

A method of preventing or reducing chemotherapy-induced alopecia is disclosed which comprises administering to a host subjected to chemotherapy which induces alopecia an effective amount of vitamin D,or derivative or analog or active metabolite thereof. The amount is sufficient to affect prevention or reduction of chemotherapy-induced alopecia.

Method of preventing and treating chemotherapy-induced alopecia with vitamin D3 or a derivative or analog or active metabolite thereof.

The present invention relates to compositions useful in the stimulation of hair growth. These compositions comprise a conditioned medium obtained from a cell culture of human mononuclear cells or a conditioned or extracted medium obtained from a cell culture of mammalian normal or transformed cells or cancer cells.

Hair growth stimulating composition

The present invention relates, in general, to a method of inhibiting alopecia, or hair loss, and, in particular, to a method of inhibiting alopecia induced by chemotherapeutic agents. The invention further relates to a composition suitable for use in such a method. Active agents for use in the above method include proteinaceous growth factors, such as EGF, and/or vitamin D.sub.3 or metabolites thereof.

Growing community of inventors

Miami, FL, United States of America

Joaquin J Jimenez