Lungpacer Medical Inc.

Simon Fraser University

Bionic Power Inc.

Neurostream Technologies General Partnership

Other

Neurostream Technologies, Inc.

Joaquin Andres Hoffer

Bao Dung Tran

Viral Thakkar

John E Nash

Douglas G Evans

Marc-Andre Nolette

Marcelo Baru

Douglas John Weber

James Maxwell Donelan

Bernard Coquinco

Gautam Sadarangani

Jessica Kit-Sum Tang

Arthur D Kuo

Ramasamy Meyyappan

Qingguo Li

Rodrigo Andres Sandoval

Steven Campbell Reynolds

Jean-Martin Vallieres

Gary Jenne

Marc-Olivier Imbeau

Thiago Gasperini Bassi

Viral S Thakkar

Kevin Daryl Strange

Marcelo Daniel Baru Fassio

Marc Andre Nolette

Enric Calderon

Albert Calderon

Ignacio Valenzuela

Klaus Kallesoe

Gary B Jenne

Douglas Weber

Marcelo D Baru Fassio

Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.

Transvascular nerve stimulation apparatus and methods

A catheter may include electrodes for transvascular nerve stimulation. The electrodes may be positioned within lumens of the catheter and aligned with apertures in the outer wall of the catheter. The electrodes may produce focused electrical fields for stimulation of one or more nerves. In one embodiment, the catheter may include a set of proximal electrodes and a set of distal electrodes, and the proximal electrodes may stimulate a patient's left phrenic nerve and the distal electrodes may stimulate a patient's right phrenic nerve.

Apparatus and methods for assisted breathing by transvascular nerve stimulation

This disclosure describes, among other embodiments, systems and related methods for selecting electrode combinations to be used during nerve pacing procedures. A first set of electrode combinations of a nerve pacing system, such as a phrenic nerve pacing system for diaphragm activation, may be mapped (or tested) to determine the location of the electrode combinations relative to a target nerve. Once the general location of the target nerve is known, a more localized second set of electrode combinations may be tested to determine the most suitable electrode combinations for nerve stimulation. At various stages of the mapping process, electrode combinations that are non-optimal may be discarded as candidates for use in a nerve pacing procedure. The systems and methods described herein may allow for the selection of electrode combinations that are most suitable for stimulation of the left and right phrenic nerves during diaphragm pacing.

Systems and related methods for optimization of multi-electrode nerve pacing

A method may include positioning a catheter, including at least one electrode, within an esophagus such that the electrode is proximate to at least one sympathetic ganglion. The methods may further include recruiting the sympathetic ganglion via an electrical signal, monitoring the recruitment of the sympathetic ganglion, and, based on the monitoring the recruitment of the sympathetic ganglion, adjusting the electrical signal from the at least one electrode.

Systems and methods for trans-esophageal sympathetic ganglion recruitment

The invention, in one aspect, relates to an intravascular electrode system. The system comprises one or more electrodes supported on an elongated resiliently flexible support member, and the support member may be used to introduce the electrodes into a blood vessel. As the support member is introduced into the blood vessel the support member bends to follow the path of the blood vessel.

Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava. The TDPS can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance/support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.

Transvascular diaphragm pacing systems and methods of use

Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic vagus, trigeminal, obturator or other nerves.

Methods of stimulating a nerve may include inserting a lead structure into one or more blood vessels. The lead structure may include an insulating member, first electrodes and second electrodes supported on the insulating member, and at least one metal lead. The first electrodes and second electrodes may be positioned in one or more blood vessels. The methods of stimulating a nerve may further include the lead structures being applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.

Diaphragm pacing systems and methods are disclosed for providing respiratory therapy to a patient. The diaphragm pacing systems can provide rapid insertion and deployment of pacing electrodes in critically ill patients who require intubation and invasive Positive Pressure Mechanical Ventilation (PPMV) in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation. The diaphragm pacing systems can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance/support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.

Diaphragm pacing systems and methods of use

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Anmore, Canada

Joaquin Andres Hoffer