Amazonia Fitomedicamentos Ltda.

Université De Sherbrooke

Joao B Calixto

Luiz Francisco Pianowski

Claudio Paulino Chaves

Pedro D'Orleans-Juste

Paulo Cesar Leal

Rosendo A Yunes

Ghassan Bkaily

Claudio P Chaves

The present invention generally refers to an active fraction of an extract of the latex of plants from the family Euphorbiaceae in a polar solvent, as well as of one or more compounds contained therein, as well as the use of said fraction and/or said compounds, particularly in the treatment of cancer. The invention also refers to compositions comprising said active fraction and/or said compounds, as well as their use for the treatment of diseases concerning cell proliferation/angiogenesis, particularly cancer.

Active fraction of a polar solvent extract from the latex of euphorbiaceae plants

The invention generally refers to pharmaceutical uses of lanosta-8,24-dien-3-ols, a family of tetracyclic terpenols, as anti-inflammatory, anticancerigenous and analgesic agents via the inhibition of the disordered activation of serine-threonine protein kinases, particularly PKC.

Pharmaceutical uses of lanosta-8,24-dien-3-ols

The present invention relates to Cachannel blockers and more particularly to the R-type Cachannel blockers. More specifically, the invention relates to Cachannel blockers activity ofand. The present invention further concerns saponin-like compounds isolated fromspecies. The present invention also relates to the treatment of several pathologies that involve the nifedipine-insensitive but isradipine sensitive steady-state R-type Cachannel and the use of steady-state R-type Cachannel blockers in the treatment of these pathologies.

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Florianopolis, Brazil

Joao B Calixto