Merck Sharp + Dohme Corp.

Other

Joanne Clare Hannam

Andrew Madin

Mark Peter Ridgill

Timothy Harrison

Ian James Collins

Janusz Jozef Kulagowski

Eileen Mary Seward

Timothy Jason Sparey

Christopher Hamblett

Jed Hubbs

Yudith Garcia

Sascha Hartmann

Janusz Josef Kulagowski

Christopher L Hamblett

Jed L Hubbs

Compounds of formula (I) are modulators of gamma-secretase, and hence are useful in treatment of Alzheimer's disease. 

Piperidines and related compounds for the treatment of Alzheimer's disease

Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer's disease and related conditions. 

Piperidines and related compounds for the treatment of dementia

Compounds of formula I: selectively inhibit production of A&#x3b2;(1-42) and hence are useful in treatment or prevention of disease associated with deposition of &#x3b2;-amyloid in the brain.

Piperidines and related compounds for treatment of alzheimer's disease

Compounds of formula I: are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of &#x3b2;-amyloid.

Gamma-secretase inhibitors

Compounds of formula I: inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.

Cyclic sulfamides for inhibition of gamma-secretase

There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising a substitute on the bridgehead position. The compounds modulate the production of the &#x3b2;-amyloid precursor protein, and hence are useful in the treatment of Alzheimer's Disease.

Growing community of inventors

Canterbury, United Kingdom

Joanne Clare Hannam