Instytut Chemii Bioorganicznej Pan

Narodowy Instytut Lekow

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Joanna Romanowska

Marcin Krzysztof Chmielewski

Andrzej Piasek

Andrzej Lipniacki

Agnieszka Szymanska-Michalak

Adam Kraszewski

Jacek Stawinski

Michal Sobkowski

Jerzy Boryski

Micha Sobkowski

The subject of the invention is a new method of the synthesis of polyphosphate analogs, such as nucleosides, oligonucleotides, carbohydrates, peptides and proteins, which are of biological importance and are used in organic chemistry, molecular biology and biotechnology. Polyphosphate analogs, including in particular nucleoside 5'-triphosphates, display high biological activity and are responsible for the provision and storage of energy in live organisms. The method relates to the synthesis of organic polyphosphates of general formula (1), where n has a value of 0 to 2, while X stands for an organic radical, in particular nucleoside, oligonucleotide, peptide-carbohydrate or a protein radical. 

Method of polyphosphate synthesis

An exemplary emboidment is related to a pharmaceutical composition of the class of nucleotide analogues and antiviral pro-nucleotides useful in partial or complete inhibition of human immunodeficiency virus (HIV). An exemplary embodiment is expressed in the formula (XVI): where X stands for Nand B stands for thymidine-1-yl, or X stands for H and B stands for uracil-1-yl or adenin-1-yl or hypoxanthin-1-yl.A method of synthesis of the nucleotide analogue using a phosphorylating agent for synthesis of the nucleotide analogue is provided.

Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition

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Luboń, Poland

Joanna Romanowska