Merck Sharp + Dohme Corp.

Joanna L Chen

Ping Liu

Joey Lee Methot

Santhosh Francis Neelamkavil

Peter H Fuller

Hakan Gunaydin

Vladimir Simov

Ling Tong

Thomas H Graham

Solomon D Kattar

Gregori J Morriello

Harold B Wood

Derun Li

Blair T Lapointe

Weiguo Liu

John J Acton, Iii

J Michael Ellis

Xin Yan

David Annunziato Candito

Michael J Ardolino

William P Kaplan

Luis Torres

Kaitlyn Marie Logan

Anmol Gulati

John Acton

Mitchell Henry Keylor

Ryan Wing-Kun Chau

The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R, R, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

The present invention is directed to substituted certain reversed indazolyl-spiro[2.2]pentane-carbonitrile derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved. 

Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

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Braintree, MA, United States of America

Joanna L Chen