Cancer Research Technology Limited

Joanna L Brookfield

Gregory R Ott

Emma Louise Carswell

Mark David Charles

Katherine M Fowler

Chukuemeka Tennyson Ekwuru

Jonathan R Roffey

Daniel James Ford

Frederic Elustondo

Mathew L Calder

Frédéric Elustondo

Emma L Carswell

The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

Pyrimidinone derivatives as CDC7 inhibitors

The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated. 

Pyrimidinone derivatives as Cdc7 inhibitors

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Cambridge, United Kingdom

Joanna L Brookfield