Centre National De La Recherche Scientifique

Centre De Recherches Biologiques Et D'experimentations Cutanees

Institut European De Biologic Cellulaire

Université Paris—sud

Centre National De La Recherche Scientifique (cnrs) Etablissement Public

Joanna Bakala

Jérôme Bignon

Maria Conception Achab

Jean-Yves Lallemand

Gisèle Franck

Pascal Collin

Bernard Delpech

Jian-Miao Liu

Michel Hocquaux

Pierre Potier

Jean-Daniel Brion

Claude Thal

Pierre Jean-Paul Potier

Samir Messaoudi

Olivier Provot

Abdallah Hamze

Maxim Egorov

Jean-Paul Pierre Potier

Nobumichi-André Sasaki

Elian Lati

Bogdan Iorga

Mouâd Alami

Anne Giraud

Franck Pelissier

Emile Benechie

Guy Jean Marie Potier, Legal Representative

Marie-Claude Denise Michèle Zelveyan, Legal Representative

Jérome Bignon

Catherine Marie Germaine Magnan, Legal Representative

Fabienne Peyrot

Denyse Herlem

Stéphanie Almeida Épouse Scalvino

Françoise Khuong-Huu

Odette Drion, Legal Representative

Michel Benechie

Françoise Lawrence

Odile Thoison

Nathalie Cheviron

Yves Fromes

Nobumichi André Sasaki

Nobumichi Andre Sasaki

Maria Concepcion Achab Garcia Alvarez

Qian Wang-Zhu

Lioudmila Ermolenko

Naima Bakrim Nhiri

Yves-Michel Frapart-Jannuad

Jean-François Peyrat

Yves-Michel Frapart-Jannaud

Nobumichi-Andre Sasaki

Maria Conception I/achib

Francoise Lawrence

Naiema Bakrim Nhiri

Pierre (deceased) Potier

Maria Achab

Naïma Bakrim Nhiri

Liu Jian-Miao

The object of the present invention relates to a novel family of peptide conjugates of formula (I):A-X-X-Pro-Ala-X&#x2014;B&#x2003;&#x2003;(I)

Peptides of use in the preventive and curative treatment of alopecia

The present invention relates to a 3-aryl-4 catechol-pyrrole-n-propanol compound and the derivatives thereof having General Formula (I), wherein:&#x2014;Ris an aryl group, particularly a phenyl, optionally substituted by one or more (C-C)alkyl groups, one or more halogens, one or more &#x2014;OH, &#x2014;CN or CFgroups, or a combination of same, and&#x2014;Ris a (C-C)alkyl group, a hydroxy(C-C)alkyl group, a (C-C)alcoxy(C-C)alkyl group, or a pharmaceutically acceptable hydrate or solvate of same. The invention also relates to the methods for preparing said compound and derivatives, to the pharmaceutical compositions containing same, and to the use of same as a drug or in the form of a prodrug converted via dimerization, particularly via oxidative coupling in the presence of a superoxide anion, in the treatment of cancer and diseases related to excessive angiogenesis. 

Use of a novel 3-aryl-4-catechol-pyrrole-N-propanol compound and the derivatives thereof to treat cancer and diseases related to excessive angiogenesis

The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n&#x2267;1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO, CF, CCI, CN, COH, (C&#x2550;O)NR, CH&#x2550;NR, (C&#x2550;S)OR, (C&#x2550;O)SR, CSR, SOR, SONR, SOR, P(O)(OR), P(O)(R), B(OR)group where R is a (C-C) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and Rand Reach represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C-C) alkyl, phenyl or phenyl-(C-C)-alkyl group, in which Rand Rform, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C-C) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same. 

N-substituted 3,4-bis (catechol) pyrrole compounds, and the preparation and use thereof in the treatment of cancer

The invention relates to a compound having general formula I, wherein: X represents CH, C&#x2550;O, C&#x2550;S or CHOH, Rrepresents an amino acid optionally substituted by one or more halogen atoms, or by one or more CFgroups and n=0.1 or 2, or Rrepresents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CFgroups and n=0 or 1, or XRrepresent POH or SOH and n=0.1 or 2; Rrepresents H, XR1, an alkyl group at C-C, an aralkyl group at C-Cor an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH, a carboxylic group COOH, one or more halogen atoms. 

Age inhibitors

This invention relates to the cosmetic use of at least one compound of formula (I) wherein

Cosmetic use of at least the natural tetrapeptide Ac-Ser-Asp-Lys-Pro or one of its analogs as a skin restructuring agent

The invention relates to a compound of the formula (I) in which: R, Rand Rare independently a methoxy group optionally substituted by one or more fluorine atoms; Ris a hydrogen atom; Rand Rare identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.

Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization

The cosmetic use of at least one compound of formula (I) wherein: Ais the radical corresponding to D- or L-Ser; Ais the radical corresponding to D- or L-Asp or Glu; Ais the radical corresponding to D- or L-Lys, Arg or Orn; Ais the radical corresponding to D- or L-Pro; R, R, Rare such as defined in the claims, as agent for controlling hair loss. 

Agent for slowing hair loss and/or stimulating hair growth

The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and Rand Ris independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or Rand Rform together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.

Pyranone derivatives useful for treating cancer

The present invention relates to the use of a compound of formula I: 

Angiogenic agents and their uses

The present invention relates to the use of biguanide derivatives of general formula I below: in which:

Use of biguanide derivatives for making a medicine having a wound healing effect

Growing community of inventors

Paris, France

Joanna Bakala