Grifols, S.a.

Joann Hotta

Brett Buno

Michael Burdick

Terri Journigan

Clark Zervos

Wytold Lebing

Doug Burns

Nathan Roth

A method of purification of non-enveloped or pseudo-enveloped virus produced in vitro uses a composition with at least one detergent. A method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample includes treating with at least one detergent.

Methods for purification of a virus produced in vitro and clearance assay for the virus

Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.

Method for generating high-titer hepatitis E virus stocks and titration assay for hepatitis E virus

A method identifies atypical antibodies in blood or blood product manufacturing processes that may produce false positives in quality control testing on intermediate or final products.

Identification of atypical antibodies in human blood and blood products

Described herein are methods for inactivating viruses using caprylate in solutions containing albumin.

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Raleigh, NC, United States of America

Joann Hotta