Eli Lilly and Company

JoAnn Hoskins

Paul Luther Skatrud

Brigitte E Schoner

Stephen W Queener

John D Sharp

Hansen M Hsiung

Pamela Kay Rockey

Genshi Zhao

Stanley Richard Jaskunas, Jr

Ruth M Kramer

Janet K Epp

Cathleen Alice Cantwell

George L Long

Ramamoorthy Belagaje

William Ernest Alborn, Jr

Roland L Hodges

Xue-Chiou C Chiou

Donald L White

Serhat Unal

The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of . Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.

Penicillin binding protein from Streptococcus pneumoniae

The present invention provides DNA compounds that encode ACV synthetase activity of,. The compounds can be used to construct recombinant DNA expression vectors for a wide variety of host cells, including,, Penicillium, Cephalosporium, and Aspergillus.

Recombinant DNA compounds that encode ACV synthetase activity of Cephalosporium acremonium

The instant invention provides the femA gene of Staphylococcus epidermidis and all degenerate sequences thereof, the protein encoded by the femA gene (FemA), and vectors and microorganisms comprising genes encoding the FemA protein.

FemA gene of staphylococcus epidermidis, femA protein, and vectors and

The invention includes recombinant DNA compounds, vectors and methods useful for expressing an exceptionally rare, human, cytosolic phospholipase A.sub.2 (cPLA.sub.2) enzyme. The invention also includes a method for screening compounds to identify inhibitors of cPLA.sub.2 which is believed to partake in several disease processes.

Compounds, vectors and methods for expressing human, cytosolic

The present invention comprises improved derivatives of the tryptophan operon useful for expressing fused gene products in E. coli and relate organism. Two of the improved derivatives disclosed are encoded on 0.43 and 0.55 kb EcoRI restriction fragments from plasmids pCZ20 and pLEBGH2 (in strains NRRL B-15881 and NRRL B-15882), respectively. The modified derivatives have been placed on recombinant DNA cloning and expression vectors. A variety of expression vectors have been constructed that drive expression of fused gene products. Two novel gene sequences, encoding insulin-like growth factors I and II, have been expressed with the modified tryptophan operon system.

Derivative of the tryptophan operon for expression of fused gene products

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Indianapolis, IN, United States of America

JoAnn Hoskins