Capsulis

Capsules

Jo&euml;lle Amedee

Ren&eacute; Laversanne

Didier Roux

OLivier Freund

Patrick Mahy

Charles Guinez

A method for oral administration of an active principle includes the steps of incorporating an active principle in multilamellar vesicles having a diameter of between 0.1 and 25 &mgr;m, and a lamellar liquid-crystal internal structure formed, from the center to the periphery of the vesicles, of a stack of concentric bilayers based on amphiphilic agents alternating with layers of water, aqueous solution or solution of a polar liquid, and orally administering a composition containing the active principle incorporated within the vesicles.

Pharmaceutical compositions for oral administration

A composition containing a plurality of multicellular vesicles and at least one nucleic acid, at least one part of which is found included inside the multilamellar vesicles. Each of the vesicles is formed of a succession of lamellar bi-layers extending from each vesicle center to its periphery and including at least one surfactant agent. The bi-layers are concentric and are separated by a liquid medium. Such compositions can be used in pharmaceutics, particularly gene therapy, and in in vitro and in vivo transfection.

Compositions containing at least one nucleic acid

Growing community of inventors

Pessac, France

Joëlle Amedee

Growing community of inventors

Pessac, France

Jo&euml;lle Amedee

Joëlle Amedee