Pierre Fabre Medicament

Jo&euml;l Bougaret

Eric Goutay

Jean-Marc Aiache

Elie Leverd

Jean-Louis Avan

Bruno Paillard

Monique Seiller

Jean-Louis Grossiord

Pascale Gauthier

Pascal Lombardin

The invention concerns liquid or pasty thixotropic compositions containing an active substance for filling capsules at room temperature. The compositions become fluid by the effect of shearing when they pass through the filling nozzle, then recover their consistency with sufficient intensity and rapidity to prevent, after filling any leak between the two capsule parts. Said compositions are characterized in that their rheological properties are specially adapted for filling and for optimal recovery of consistency. They are preferably in the form of dispersions supporting amphiphilic excipients. Said compositions enable the formulation of active liquid, pasty and even solid substances.

Thixotropic formulations for filling capsules

The invention concerns a pharmaceutical composition with prolonged release, for oral administration of a single daily dose of 60 to 140 mg of Milnacipran, having a multi-particulate form containing a plurality of microgranules each comprising an active microsphere containing a saccharose and/or starch nucleus of a size between 200 and 2000 &mgr;m and containing 150 to 1000 &mgr;m of Milnacipran and a binding agent, each microgranule being coated with a film having a base of at least one polymer insoluble in water but permeable to physiological liquids, of a thickness between 20 and 100 &mgr;m, the said pharmaceutical composition enabling an in vitro release corresponding to the following pattern: between 10 and 55% of the dose released in 2 hours, between 40 and 75% of the dose released in 4 hours, between 70 and 90% of the dose released in 8 hours, between 80 and 100% of the dose released in 12 hours.

Pharmaceutical composition with extended release of Milnacipran

The invention concerns multilayer microspheres containing an acid substance, a basic substance, and a water-soluble isolating agent which, when it dissolves in water, after almost instant effervescence, brings about a homogeneous dispersion of active principal(s) which is present in the acid and basic substances. The invention also concerns a method for preparing such microspheres by rotational granulation on a fluid air bed associated with a system of tangential spraying of the wetting liquid.

Effervescent microspheres and method for making them

Growing community of inventors

Lanta, France

Joël Bougaret

Growing community of inventors

Lanta, France

Jo&euml;l Bougaret

Joël Bougaret