Arrayjet Limited

Joan Salvatella Serra

Benjamin Mitchell

Marisa Chong-Kwan

Method for manufacturing a microarray and verifying the quality of said microarray, wherein the method comprises: &#x2014;providing at least one reagent, &#x2014;loading said at least one reagent in a dispensing print head, in a predetermined arrangement, &#x2014;moving the print head with respect to a substrate and dispensing said at least one reagent on the substrate, during a print pass, to obtain a microarray, &#x2014;illuminating the substrate using illumination means and obtaining an image of the printed microarray on the substrate, using a camera, &#x2014;processing the obtained image to verify the quality of the microarray, wherein the step of obtaining an image of the printed microarray comprises: &#x2014;illuminating the substrate and obtaining an image of the microarray by means of illumination means and a camera which are connected to and move together with the print head with respect to the substrate, the illumination means and the camera being adapted to move behind the print head.

Method and device for producing a printed microarray and verifying the same

Method for manufacturing microarrays and verifying the quality of said microarrays, wherein the method comprises: a) providing at least one reagent, b) loading said at least one reagent in a dispensing print head, in a predetermined arrangement, c) in a first print pass, generating instructions for the print head and moving said print head with respect to a substrate to print said at least one reagent on the substrate to obtain microarrays, d) obtaining an image of the printed microarrays by means of a camera, e) processing the obtained images of the printed microarrays, to calculate parameters indicative for the quality of the printed microarrays, f) comparing, at the end of the first print pass, the calculated parameters for the printed microarrays with predetermined criteria for the microarrays, to identify possible printing defects, g) comparing, for the printed microarrays, the identified printing defects of step f), h) using the outcome of the comparison of step g) to select a corrective action to improve the quality of the microarrays, prior to the printing of a subsequent print pass.

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Edinburgh, United Kingdom

Joan Salvatella Serra