Sanifit Therapeutics S.a.

Numat Biomedical, S. L.

Laboratories Sanifit, S. L.

Universitat De Les Illes Balears

Numat Medtech, S.l.

Joan Perelló Bestard

Bernat Isern Amengual

Fernando Tur Espinosa

Paula Mendoza De Las Heras

Eva Tur Tur

Ciriaco Maraschiello De Zuani

Marta Monjo Cabrer

Joana María Ramis Morey

Eva Martín Becerra

Marco Antonio Moreno Santurino

Rubén Henríquez Paláez

María Del Mar Arriero Sánchez

Antonia Costa-bauzá

Iréne Lenthéric

Máximo Encabo Alarcón

María Del Mar Arriero SÁNCHEZ

Rafael Mará Prieto Almirall

Ramón GARCÍA GONZÁLEZ

The present invention provides processes for preparing soluble salts of inositol phosphate characterized by a low level of impurities. Processes for preparing soluble salts (e.g., alkali-metal or ammonium) of inositol phosphates (e.g., hexasodium or dodecasodium salts), and of inositol hexaphosphate in particular (e.g., NaIPand NaIP), are described. Also provided are pharmaceutical compositions, methods of use, combination treatments, kits, and articles of manufacture comprising soluble salts of inositol phosphates prepared according to the method of the invention.

Processes for the preparation of soluble salts of inositol phosphates

The present invention relates to a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein a compound selected from the group consisting of an IP, an ester of an IP, and/or a pharmaceutically acceptable salt thereof, or a combination thereof, is/are covalently bound to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. The covalent bond between the IP and the metal, metal alloy or metal oxide surface can be further assisted by the use of a linker. An implant according to the invention provides for a modulated and/or improved osseointegrative effect when implanted into a body, such as a mammalian body, by virtue of the coating comprising covalently bound phytate.

Biocompatible implant

Growing community of inventors

Palma De Mallorca, Spain

Joan Perelló Bestard