Novartis Ag

University of Pennsylvania

University of Massachusetts

University of Virginia

Restorbio, Inc.

Joan Mannick

David Jonathan Glass

Leon Murphy

Jennifer Brogdon

Michael C Milone

Qilong Wu

Yongqiang Wang

Marco Ruella

Carl H June

Andreas Loew

Saar Gill

Hilmar Erhard Ebersbach

Jiquan Zhang

Saad Kenderian

David L Porter

Reshma Singh

Celeste Richardson

Huijuan Song

William Raj Sellers

Melody Morris

Gabriela Plesa

Heather Huet

Eugene Choi

Brian Edward Vash

Jan Weiler

Boris Engels

Brian Walter Granda

Li Zhou

Lai Wei

Qiumei Yang

Julia Jascur

John Hastewell

Thomas Huber

Marcela V Maus

Abhishek Garg

John C Byrd

Benjamin M Gaston

Mariusz Wasik

Natarajan Muthusamy

Avery D Posey

Amy Jo Johnson

Jan J Melenhorst

Jason A Dubovsky

Felipe Bedoya

Hans Bitter

Elena Orlando

Nicholas Wilcox

Jihyun Lee

Barbara Leinweber

Joseph Fraietta

Grace Teo

Chen Schor

Corin Dorfmeier

Abhishnek Garg

The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Treatment of cancer using humanized anti-BCMA chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.

Treatment of cancer using a CD123 chimeric antigen receptor

Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.

Regulatable chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.

Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor

Anti-BCMA chimeric antigen receptor

The present invention relates to a method of enhancing immune response in a subject.

Methods of enhancing immune response

Cancer biomarkers and methods of using them are disclosed.

Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof

The present invention provides methods and pharmaceutical compositions for the treatment or prevention of autophagy-related diseases, disorders, or conditions.

Combination therapies

The present invention relates to a combination comprising (a) RAD001, or a pharmaceutically acceptable salt thereof, and (b) BEZ235, or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential use for enhancement of an immune response; a pharmaceutical composition comprising such combination; a method of enhancing immune response in a subject comprising administration of said combination to a subject in need thereof; use of such combination for preparation of a medicament for the enhancement of an immune response; and a commercial package thereto.

Pharmaceutical combination of everolimus with dactolisib

The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors encoding the same, and recombinant cells comprising the CLL-1 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CLL-1 binding domain.

Treatment of cancer using a CLL-1 chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.

Treatment of cancer using anti-CD19 Chimeric Antigen Receptor

The present invention relates, in part, to compositions and methods for enhancement of an immune response by partial mTOR inhibition, e.g., with low, immune enhancing, doses of an mTOR inhibitor, such as RAD001.

Low, immune enhancing, dose MTOR inhibitors and uses thereof

Growing community of inventors

Cambridge, MA, United States of America

Joan Mannick