University of Pennsylvania

The Wistar Institute

Joan M Von Feldt

David B Weiner

William Valentine Williams

Thomas Kieber-Emmons

A method of identifying peptides which mimic biologically active proteins is disclosed. The method comprises the steps of making a recombinant antibody library from genetic material obtained from an animal which has been immunized against antibodies that bind to the biological active protein to the mimicked. Recombinant antibodies are screened to identify antibodies which compete with the biological active protein. Peptides which comprise the recombinant antibody's CDR sequences are synthesized. Synthetic peptides which mimic GM-CSF are also disclosed.

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Wilmington, DE, United States of America

Joan M Von Feldt