Tocagen Inc.

Immusol, Incorporated

Denovo Biopharma LLC

Joan M Robbins

Douglas J Jolly

Harry E Gruber

Amy Lin

Tiffany Huang

Richard Tritz

Omar D Perez

Derek G Ostertag

Ryan Burnett

Amy H Lin

The disclosure provides vectors for treating cancers, method of producing such vectors and methods of use of the vectors.

Retroviral vector having immune-stimulating activity

This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

Compositions comprising gamma retrovirus vectors and methods of treating proliferative disorders

This disclosure relates to a combination therapy of chemotherapeutics and/or radiosensitizing agents with a replication competent viral vectors for treating cell proliferative disorders and chemotherapeutic treatments. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

Cancer combination therapy and recombinant vectors

As an effective therapy for proliferative skin and eye diseases such as psoriasis and proliferative diabetic retinopathy, this invention provides ribozymes and ribozyme delivery systems which cleave RNA encoding cytokines involved in inflammation, matrix metalloproteinases, a cyclin, a cell-cycle dependent kinase, a growth factor, or a reductase.

Ribozyme therapy for the treatment of proliferative skin and eye diseases

Growing community of inventors

San Diego, CA, United States of America

Joan M Robbins