Wyeth

Joan E Sabalski

Gregory Scott Welmaker

Annmarie Louise Sabb

Robert Lewis Vogel

Anthony Frank Kreft

Thomas Joseph Caggiano

James Albert Nelson

Donna Mary Huryn

Sharon J Rosenzweig-Lipson

Koi Morris

Lynn Resnick

Dennis Martin Kubrak

Michael D Smith

Joshua D Berkowitz

John Anthony Butera

Eugene John Trybulski

Geraldine Ruth McFarlane

David R Herbst

Matthew A Wilson

Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: wherein, Ris lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SOR; Ris phenyl, substituted phenyl, heterocycle, substituted heterocycle, alkyl, or substituted alkyl; Ris lower alkyl, substituted lower alkyl, CF, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; Ris hydrogen, lower alkyl, or substituted lower alkyl; Ris phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; Ris hydrogen, lower alkyl, substituted lower alkyl, CF, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, cycloalkyl, or substituted cycloalkyl; W, X and Y are independently CRor N; and Ris hydrogen, halogen, lower alkyl, or substituted lower alkyl.

Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole

The present invention is directed to compounds of Formula I: that are potassium channel modulators and pharmaceutical compositions thereof. The present invention is further directed to methods of treatment using the compounds and pharmaceutical compositions of the invention. The present invention is still further directed to synthetic processes for producing the compounds of the invention.

Benzofurans as potassium ion channel modulators

Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: 

This invention provides processes for preparing compounds formula: wherein R is H, alkyl, acyl, aryl, aroyl or &#x2014;C(O)R'; R&#x2032; is alkyl or aryl; R, R, Rand Rare H, &#x2014;OH, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl or alkoxy, &#x2014;CN, &#x2014;NH&#x2014;SO-alkyl, &#x2014;SO&#x2014;NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, acyl, aryl or aroyl; Ris H, alkyl, cycloalkyl, alkoxy, fluorinated alkyl, &#x2014;NH&#x2014;SO-alkyl, &#x2014;SO&#x2014;NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated alkoxy, acyl, aryl, or aroyl; or a pharmaceutically acceptable salt thereof, as well as novel compounds useful in the synthesis of these compounds.

Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives

This invention provides compounds of the formulae: wherein:

Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives

Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives

Cyclopenta&lsqb;b&rsqb;&lsqb;1,4&rsqb;diazepino&lsqb;6,7,1-hi&rsqb;indoles and derivatives

&lsqb;1,4&rsqb;diazepino &lsqb;6,7,1-jk &rsqb;carbazoles and derivatives

Process for preparation of cyclopenta&lsqb;b&rsqb;&lsqb;1,4&rsqb;diazepino&lsqb;6,7,1-hi&rsqb; indole derivatives

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Hamilton, NJ, United States of America

Joan E Sabalski