Rutgers, the State University of New Jersey

Icahn School of Medicine at Mount Sinai

Joan E Durbin

Adolfo Garcia-Sastre

Sergei V Kotenko

Viralkumar Rameshkumar Davra

Peter Palese

Ignacio Mena

Russell K Durbin

Described herein are recombinant Newcastle disease viruses ('NDVs') comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a respiratory syncytial virus (“RSV”) F protein or human metapneumovirus (“hMPV”) F protein. Also described herein are recombinant NDVs comprising a packaged genome, wherein the packaged genome comprises a transgene encoding a chimeric F protein, wherein the chimeric F protein comprises (i) an RSV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains; or (ii) an hMPV F protein ectodomain and NDV F protein transmembrane and cytoplasmic domains. The recombinant NDVs and compositions thereof are useful for the immunizing against RSV or hMPV as well as the prevention of RSV disease or hMPV disease.

Recombinant Newcastle disease viruses and uses thereof for the prevention of RSV disease or human metapneumovirus disease

Fusion molecules composed of a type I interferon protein or portion thereof and a type III interferon protein or portion thereof, pharmaceutical compositions containing the fusion molecules, and methods for their use in inhibiting infection, inhibiting or treating cancer, inducing signaling of transcription of IFN-stimulated genes through an IFN-&#x3b1;R2 chain in a subject suffering from an infection which degrades or downregulates an IFN-&#x3b1;R1 chain, and treating various diseases or conditions are provided.

Type I and type III interferon fusion molecules and methods for use thereof

Growing community of inventors

Sergeantsville, NJ, United States of America

Joan E Durbin