Regeneron Pharmaceuticals, Inc.

Joan A Windsor

Sean Stevens

Joel H Martin

Jeanette L Fairhurst

Kevin J Pobursky

Warren R Mikulka

Nicholas J Papadopoulos

Tammy T Huang

Ashique Rafique

Ergang Shi

Raymond W Leidich

Diana M Ahrens

Marcela Torres

Margaret Karow

Tammy H Huang

Warren R Mikluka

An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R&#x3b1;) with an affinity constant (K) of less than 200 pM, as measured by surface plasmon resonance, is provided.

High affinity human antibodies to human IL-4 receptor

An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18R&#x3b1;), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.

High affinity human antibodies to human IL-18 receptor

The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.

An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R&#x3b1;) with an affinity constant (K) of less than 200 pM, as measured by surface plasmon resonance.

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Brooklyn, NY, United States of America

Joan A Windsor