Hoechst Aktiengesellschaft

Beiersdorf Ag

Per Immune Holdings, Inc.

Joachim Thiem

Oliver Scheel

Gunther Schneider

Merten Schlingmann

Hans-Matthias Deger

Matthias Kreuzer

Wolfram Fritsche-Lang

Reinhold Keller

Matthias Wiesner

Hartmut Schmidt-Lewerkuhne

Wolfgang Treder

Susanne Grabley

Cenek Kolar

Reinhard Bredehorst

Hans P Kraemer

Nicholas Pomato

Hartmut Voelskow

G&uuml;nther Schneider

Hans-Ullrich Hoppe

Hartmut Schmidt-Lewerk&uuml;hne

Torsten Wiemann

Martina Lahmann

Alkyl 2-acetamido-2-deoxy-D-glucopyranoside uronic acids, and their pharmaceutically or cosmetically acceptable salts, and their use as surface-active and/or interfacially active active compounds, in particular as detergent surfactants or emulsifiers.

Alkyl 2-acetamido-2-deoxyglucopyranoside and methods of emulsifying

Alkyl 2-acetamido-2-deoxyglucopyranoside uronic acids and derivatives,

Alkyl 2-acetamido-2-deoxyglucopyranoside uronic acids and their

Cosmetic or pharmaceutical preparations, characterized by an effective content of pharmaceutically and/or cosmetically acceptable glycoglycerolipids.

Cosmetic or dermatological preparations containing glycoglycerolipids

Cosmetic ceutical formulations characterized by an effective, content of pharmaceutically and/or cosmetically unobjectionable hexosyl glycerides and/or (hexosyl)hexosyl glycerides.

Cosmetic formulations having an effective content of glycosyl glycerides

Tocopheryl glycosides of the general formula ##STR1## or of the general formula ##STR2## where n can adopt values of 0-6 and where R represents a radical from the group consisting of H, branched and unbranched alkyl of 1-18 carbon atoms, branched and unbranched acyl of 1-18 carbon atoms, and where R within one molecule can be identical in all positions of tie glycosyl groups, but can also adopt different meanings within one molecule, such that it is possible within one molecule to choose any desired combinations of the radicals represented.

Tocopheryl glycosides, their preparation, and their use as surfactants,

The present invention is directed to a new process for the production of chitin oligomers, including fragmentation, partial hydrolysis and recovery. This process produces high yields, especially of higher (tetra- to deca-) chitin oligomers.

High yield preparation of dimeric to decameric chitin oligomers

The invention relates to a process for the enzymatic synthesis of 2-deoxy-.beta.-D-galactosides. The enzyme galactosyltransferase is able to catalyze the transfer of 2-deoxygalactose residues from the donor substrate uridine 5'-diphospho-2-deoxy-D-galactose to N-acetylglucosamine or aspartyl-N-acetylglucosamine or, in the presence of lactose, to terminal glucose.

Process for the enzymatic synthesis of 2-deoxy-.beta.-D-galactosides

Disaccharide fluorides can be prepared by incubation of .alpha.-D-glycosyl fluorides in concentrated solutions with .alpha.-glycosidases.

Process for the enzymatic preparation of disaccharide fluorides using

.alpha.-Glucosyl fluoride can be converted in the presence of cyclodextrin .alpha.(1.fwdarw.4)glucosyltransferase into a mixture of .alpha.- and .beta.-cyclodextrins in high yield.

Enzymatic synthesis of cyclodextrins using .alpha.-glucosyl fluoride as

Streptazoline is reacted with naphthoquinones in a Diels-Alder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.

Diels-alder adduct from streptazoline and naphthoquinones and its

Alkylated glycosyl fluorides free from hydroxyl groups can be prepared by converting glycosyl fluorides which still contain hydroxyl groups into the alkylated compounds in the manner of Williamson's ether synthesis in the presence of basic systems by means of alkylating agents.

Process for the preparation of alkylated glycosyl fluorides free from

Glycosyl halides which are O-acylated or O-alkylated at least in the 2-position are transhalogenated with alkali metal hydrogen difluorides in a polar-aprotic solvent and, if appropriate, the product is anomerized with the addition of less than the stoichiometric amounts of an inorganic fluoride with a Lewis acid character. Depending on the substrate, the glycosyl fluorides with the 1,2-trans or 1,2-cis configuration are obtained.

Process for the preparation of glycosyl fluorides protected on the oxygen

A process for the manufacture of glycosides which comprises reacting a protected hexopyranosyl fluoride with an aglycon or a silyl ether thereof in the presence of a metal fluoride of group IV or V of the periodic table, said metal having an atomic number of at least 22 and being present in the fluoride in a higher, stable and non-oxidizing or weekly oxidizing stage.

Process for the preparation of glycosides from glycosyl fluorides

1-Azidoaldoses are obtained by reacting 1-fluoroaldoses with metal azides in polar, water-miscible, preferably water-containing, solvents. The hydroxyl groups do not react at the same time, so that they need not be protected or can be present in a derivatized form.

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Hamburg, Germany

Joachim Thiem