Schering Aktiengesellschaft

Scharing Aktiengesellschaft

Joachim Siegert

Thomas Fritzsch

Volkmar Uhlendorf

Dieter Heldmann

Michael Stein

Georg Roessling

Ulrich Speck

Ned S Rasor

Celal Albayrak

Michael Reinhardt

Ingfried Zimmermann

Jurgen Hilmann

Matthias Rothe

Lothar Lange

Georg Ro/ Ssling

A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein an examination area is acoustically irradiated, nonlinear oscillations are produced in the examination area by irradiated ultrasonic waves and the signal is evaluated by an ultrasonic converter. Also, a circuit for carrying out the above process is disclosed.

Ultrasonic processes and circuits for performing them

The invention relates to ultrasonic contrast agents consisting of microparticles which consist of amyloses and synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60&deg; C., process for the preparation thereof and their use as diagnostic and therapeutic agents.

Ultrasonic contrast agents, process for their preparation and their use as a diagnostic and therapeutic agent

The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60&deg; C., processes for the preparation thereof and their use as diagnostic and therapeutic agents.

Agents and methods for enhancing contrast in ultrasound imaging

The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymer which is a polyalkylcyanoarylate and a gas and/or a fluid with a boiling point below 60.degree. C., processes for the preparation thereof and their use as diagnostic and therapeutic agents.

Polyalkylcyanoacrylate agents and methods for enhancing contrast in

A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein a material is introduced in the examination area to be acoustically irradiated, nonlinear oscillations are produced in the examination area by irradiated ultrasonic waves and the signal is evaluated by an ultrasonic converter. Also, a circuit for carrying out the above process is disclosed.

Microparticles comprising biodegradable polymers, characterized in that they are synthesized from polymerizable aldehydes, which optionally contain additives and/or crosslinkers capable of copolymerization, optionally surfactants or surfactant mixtures, gases and/or highly volatile liquids in free or bound form, coupling agents, optionally biomolecules or macromolecules bound by these coupling agents as well as optionally diagnostically or therapeutically effective components, are suitable as ultrasonic contrast media.

Contrast media synthesized from polyaldehydes

The invention relates to a method for obtaining an ultrasonic image of a patient with ultrasonic color Doppler modality with microparticulate ultrasonic contrast agents in regions where the ultrasonic contrast agents are essentially motionless.

Ultrasonic contrast agents for color Doppler imaging

Microparticles which are less than 12 .mu.m in size and are formed of or comprise a solid lipophilic group-containing compound having an HLB value less than about 20 produce a long lived ultrasonically echogenic entity in aqueous liquid and are useful as left heart ultrasonic contrast image enhancing agents. Contrast media for ultrasonic diagnostics comprising a liquid vehicle containing (a) suspended therein microparticles of a mixture of at least one (C.sub.8 -C.sub.20)-fatty acid and at least one solid that is not a surfactant and (b) microbubbles, are especially effective upon ultrasonic imaging after intravenous administration, for the contrasting of both the right heart and left heart, of the myocardium, as well as other organs, such as liver, spleen, and kidneys.

Growing community of inventors

Berlin, Germany

Joachim Siegert