Basf Se Corporation

Joachim Schmidt-Leithoff

Rocco Paciello

Gunnar Heydrich

Ansgar Gereon Altenhoff

Nawid Kashani-Shirazi

Christoph Jäkel

Michael Rack

Joachim Rheinheimer

Klaus Ebel

Wolfgang Krause

Matthias Rauls

Gabriele Gralla

Sebastian Peer Smidt

Steffen Oehlenschläger

Marko Friedrich

Eike Johannes Bergner

Kathrin Wissel-Stoll

Nina Challand

Wolfgang Von Deyn

Michael Keil

Thomas Zierke

Joachim Dickhaut

Volker Maywald

Karsten Koerber

Florian Kaiser

Arun Narine

Juergen Langewald

Nina Gertrud Bandur

Prashant Deshmukh

Karsten Körber

Jürgen Langewald

Christian Rein

Christoph Jäkal

The present invention relates to a particularly economic overall method for producing menthol, specifically for producing optically active, essentially enantiomerically and diastereomerically pure L-menthol and racemic menthol, starting from the starting material citral which is available inexpensively on an industrial scale. The method has the following steps

Method for producing optically active, racemic menthol

The present invention relates to a process for producing aromatic carbonyl compounds of formula I and aromatic imine compounds of formula III comprising the step of reacting a (hetero)aromatic halogen or sulfonate compound II wherein the variables are as defined in the claims and description,with a mixture of carbon monoxide and hydrogen in the presence of a transition metal complex catalyst. The invention also relates to specific compounds III, to compositions comprising them and to their use for combating invertebrate pests.

Process for producing imine compounds for combating invertebrate pests

Process for the preparation of aromatic and heteroaromatic carboxylic acids, carboxylic acid esters and carboxamides by the reaction of aromatic or heteroaromatic halides R&#x2014;X, in which n=integer from 1 to 6, R=substituted or unsubstituted and aromatic or heteroaromatic radical and X=chlorine, bromine or iodine atom, with carbon monoxide and water, ammonia, alcohols or amines in the presence of bases and zero-valent or divalent palladium compounds and bidentate diphosphanes or complexes of zero-valent or divalent palladium with bidentate diphosphanes, in which use is made of bidentate diphosphanes(R&#x2014;)(R&#x2014;)P&#x2014;Y&#x2014;P(&#x2014;R)(&#x2014;R)in which Rto R=unsubstituted aryl radicals or aryl radicals substituted with at least one radical exhibiting a positive resonance effect or a positive inductive effect, or unsubstituted or substituted cycloalkyl radicals, and Y=hydrocarbon group with a total of 2 to 20 carbon atoms, in which at least one of the carbon atoms carries only one or no hydrogen atom as substituent; except for the reaction of 4-bromo-3-difluoromethyl-1-methylpyrazole with 2-(3,4,5-trifluorophenyl)aniline and carbon monoxide to give N-[2-(3,4,5-trifluorophenyl)phenyl]-3-difluoromethyl-1-methylpyrazole-4-carboxamide.

Method for producing aromatic and heteroaromatic carboxylic acids, carboxylic acid esters and carboxylic acid amides

A process for preparing substituted biphenyls of the formula I     or a mixture of IVa and IVb.

Method for producing substituted biphenyls

The present invention relates to a particularly economic overall method for producing menthol, specifically for producing optically active, essentially enantiomerically and diastereomerically pure L-menthol and racemic menthol, starting from the starting material citral which is available inexpensively on an industrial scale. The method comprises the following steps a) catalytic hydrogenation of neral and/or geranial to give citronellal, b) cyclization of citronellal to isopulegol in the presence of an acidic catalyst, c) purification of isopulegol by crystallization and d) catalytic hydrogenation of isopulegol to give menthol.

The present invention relates to a continuous process for preparing neral (cis-citral) in pure or enriched form by distillatively separating neral from substance mixtures comprising essentially neral and geranial (trans-citral). This distillative separation is performed in a dividing wall column or in a connection of two distillation columns in the form of a thermal coupling.

Continuous process for preparing neral in pure or enriched form

The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which Ris optionally substituted phenyl or C-C-cycloalkyl, Ris hydrogen or fluorine, or Rtogether with Ris optionally substituted C-C-alkanediyl or C-C-cycloalkanediyl, Ris C-C-alkyl, C-C-alkenyl, C-C-alkynyl or C-C-alkoxy-C-C-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprisesA) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and Rhas one of the meanings given above andB) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R, Rand n have one of the meanings given above; in the presence of a palladium catalyst;to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.

Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides

The present invention relates to a process for preparing optically active carbonyl compounds by asymmetrically hydrogenating &#x3b1;,&#x3b2;-unsaturated carbonyl compounds in the presence of optically active transition metal catalysts which are soluble in the reaction mixture and have at least one carbon monoxide ligand, the optically active catalyst which has at least one carbon monoxide ligand and is to be used in each case being prepared by pretreating a catalyst precursor with a gas mixture comprising carbon monoxide and hydrogen and the asymmetric hydrogenation being performed in the presence of carbon monoxide supplied additionally to the reaction mixture.

Method for synthesizing optically active carbonyl compounds

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Mannheim, Germany

Joachim Schmidt-Leithoff