Merck Patent Gesellschaft MIT Beschrankter Haftung

Hoechst Aktiengesellschaft

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Arzneimittelwerk Dresden Gmbh

Joachim Kinkel

Ludwig Pohl

Klaus Unger

Kurt Marquard

Herbert Giesche

Hermann Dallmann

Hartwig Hocker

Friedhelm Eisenbeiss

Gottfried Blaschke

Werner Muller

Margot Mack

Werner Broker

Hans-Daniel-Jakob M&uuml;ller

Werner Fraenkel

Roger-Marc Nicoud

Ulrich Voigt

Heinz Berndt

Roland Hempel

Rolf Kuropka

A continuous process for the preparation of inorganic and organic bead polymers using a static micromixer is disclosed. The bead polymers obtainable by the process according to the invention have a very uniform particle size distribution, which can be set in a range of between 0.1 and 300 &mgr;m.

Method for producing bead polymers

The present invention relates to a novel chromatographic process which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the simulated moving bed method (SMB). The cyclosporin A obtained corresponds both to the quality requirements of USP XXIII and of EUROPEAN PHARMACOPOEIA, 2nd Edition 1995.

Chromatographic process for obtaining highly purified cyclosporin A and related cyclosporins

Molded bodies made of polyester containing covalent-bonded oxide

Surface-modified oxide particles and their use as fillers and modifying

The invention is directed to separating materials comprising a primary or secondary aliphatic hydroxyl group-containing support coated with at least one covalently bonded polymer, wherein

Separating materials

The invention relates to separating materials for thin-layer chromatography, based on sorbent-coated supports, the sorbent essentially comprising optically active poly(meth)acrylamides bonded to silica gel, and a binder system comprising a mixture of carboxyl-containing polyvinyl and acrylate polymers.

The invention relates to silane derivatives of the formula I ##STR1## their preparation by hydrosilylation of corresponding (meth)acrylamides and their use as silylating agents.

Silane coated inorganic materials for chromatography

Highly monodispersed nonporous spherical SiO.sub.2 particles are prepared having mean particle diameters between 0.05 and 10 .mu.m with a standard deviation of not more than 5% and a method for the preparation of such particles. The particles can be produced by a two step process wherein first a sol of primary particles is prepared by hydrolytic polycondensation of tetraalkoxysilanes in an aqueous/alcoholic ammoniacal medium. The SiO.sub.2 particles are then converted to the desired particle size by a continuous measured addition of tetraalkoxysilane or organotrialkoxysilane controlled by the extent of the reaction. The SiO.sub.2 particles produced by this process are particularly useful as sorption material in chromatography.

Spherical SIO.sub.2 particles

Absorbents based on optically active poly(meth)acrylamides, e.g. bonded to silica gel, can be used for separating racemic mixtures into their optical antipodes.

Optically active adsorbents

Spherical SiO.sub.2 particles

Growing community of inventors

Guldental, Germany

Joachim Kinkel