Autodisplay Biotech Gmbh

Other

Henkel Ag & Company, Kgaa

Zyrus Beteiligungsgesellschaft Mbh & Co. Patente I Kg

Heinrich-heine Universitat Dusseldof

Heinrich-heine-universitat Dusseldorf

Jose, Joachim

Joachim Jose

Thomas Weber

Andreas Taden

Roland Breves

Irmgard Schmidt

Jae-Chul Pyun

Birgit Veith

Rita Bernhardt

Frank Hannemann

Claudia Götz

Christian Detzel

Shanna Sichwart

Hans-Jorg Hemmerling

Iasson Tozakidis

Ruth Maas

Mark George Teese

Claudia Reicheneder

Andreas Gratz

Uwe Kuckländer

Nicola Steffan

Eva Elisabeth Kranen

Ruth Maria Maas

Shu-Ming Li

Stephanie Schumacher

Hans-Jörg Hemmerling

The present invention relates to a method for the surface display of a recombinant polypeptide on the surface of a host cell, said method comprising the steps: (a) providing a host cell transformed with a nucleic acid fusion operatively linked with an expression control sequence, said nucleic acid fusion comprising: (i) a portion encoding a signal peptide, (ii) a portion encoding the recombinant polypeptide to be displayed, (iii) a portion encoding a transmembrane linker, and (iv) a portion encoding the trans porter domain of an EhaA protein, and (b) culturing the host cell under conditions wherein the nucleic acid fusion is expressed and the expression product comprising the recombinant polypeptide is displayed on the surface of the host cell.

Surface display of functional proteins in a broad range of gram negative bacteria

The present invention relates to peptides, in particular dodecapeptide-containing coating agents, adhesion promoters or adhesives for oxidic surfaces, a multilayer composite or a coated substrate, containing compounds which are formed entirely or in part of dodecapeptides as adhesion promoters between at least two adjacent layers of the composite or between the coating and the substrate, and to dodecapeptides that can be used as coating agents, adhesion promoters or adhesives for oxidic surfaces.

Peptides that can be used in coating agents, adhesion promoters or adhesives for oxidic surfaces

The present invention refers to a method for binding a recombinant polypeptide to a carrier, wherein a layer is bound to a carrier, and the layer comprises a recombinant polypeptide on the surface distal to the carrier.

Method for binding a recombinant polypeptide to a carrier

The invention relates to a pharmaceutical product comprising a dibenzofuranone derivative as the active ingredient. The invention further relates to the use of dibenzofuranone derivatives to inhibit kinases, in particular serine/threonine kinases, to the use of dibenzofuranone derivatives for producing drugs and/or medicinal products for treatment, and to the use of dibenzofuranone derivatives as a diagnostic product for analyzing the role of protein kinases, in particular serine/threonine kinases, in particular protein kinase CK2 in cellular processes, the pathogenesis of diseases, ontogenesis and/or other developmental biological phenomena or relationships.

Use of dibenzofuranone derivatives to inhibit kinases

The present invention relates to a method for producing a product of a reaction catalysed by a nitrilase, which method comprises the steps (i) providing a microorganism comprising said nitrilase located on its surface, and/or a membrane preparation of said microorganism, and (ii) contacting the microorganism and/or the membrane preparation thereof with one or more nitrilase substrates under conditions compatible with nitrilase activity. The present invention further relates to a method for producing enantiomerically pure (R)-mandelic acid using the nitrilase-displaying whole cell biocatalyst or membrane preparation thereof for the conversion of racemic mandelonitrile.

Whole cell biocatalyst

Synthesis of novel substituted indeno[1,2-b]indole derivatives of the type of 5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-diones and 5H-indeno[1,2-b]indole-6,9,10-triones, which show pronounced inhibition of the human protein kinase CK2, and the use thereof as active ingredients in medicaments and/or drug products in particular for the treatment of neoplastic diseases.

Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids

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Düsseldorf, Germany

Joachim Jose