Bayer Aktiengesellschaft

Schwarz Pharma Ag

Bayer Aktiengelsellschaft

Joachim Hutter

Alexander Straub

Martin Bechem

Jurgen Stoltefuss

Siegbert Hebisch

Rainer Gross

Siegfried Goldmann

Howard-Paul Rounding

Horst Boshagen

Elisabeth Perzborn

Erwin Bischoff

Ulrich E Muller

Ulrich Rosentreter

Volker-Bernd Fiedler

Peter Norman

Nigel J Cuthbert

Hilary P Francis

Marie G McKenniff

Klaus Dembowsky

Ulrich Niewohner

Johannes-Peter Stasch

Dieter Arlt

Matthias Schramm

Thomas Jaetsch

Achim Feurer

Gerhard Franckowiak

Raimund Kast

Klaus Sandrock

Helmuth Schutz

Chantal Furstner

Eike Noack

Siegfried Goldman

Horst Bohagen

Ranier Gross

Heterocyclylmethyl-substituted pyrazole derivatives and their use for

Purin-6-one derivatives are prepared by acylating appropriately substituted imidazole carboxamides and then cyclizing to give the purines. The purin-6-one derivatives are suitable as active compounds in medicaments, in particular for the treatment of cardiovascular disorders, disorders of the vascular system and of the urogenital system.

Purin-6-one derivatives

The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

4-bicyclically substituted dihydropyridines, and their use in medicaments

The invention relates to new 2,6-disubstituted 4-quinolyl-dihydropyridines ##STR1## in which R.sub.1 to R.sub.5 have the meaning indicated in the description, processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.

2,6-disubstituted 4-quinolyl-dihydropyridines

The invention relates to new 4-quinolyl-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.6 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.

Quinolyl-dihydropyridine esters, processes for their preparation, and

The present invention relates to new 2-amino-5-cyano-4-quinolyl-l, 4-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.

2-amino-5-cyano-4-quinolydihydropyridine esters, processes for their

The invention relates to new 3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

3-quinolyl-substituted dihydropyridines and their use in medicaments

The present invention relates to new 2-amino-4-heteroaryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.4 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.

Certain cinnoline carboxaldehydes and naphthyridine carboxaldehydes

The invention relates to novel, condensed 4-quinolyl-dhydropyridines of the general formula (I) ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, in particular in agents for treating angiocardiopathies.

Condensed quinolyl-dihydropyridines, processes for their preparation and

The present invention relates to new 2-amino-4-hetero-aryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.4 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.

2-amino-4-heteroaryl-1,4-dihydropyridines and their use in medicaments

The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

Process for preparing 1,4-dihydro-2-amino-3-carboxy-5-cyano-pyridine

New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including circulatory diseases, high blood pressure, cardiac insufficiency and for dilating the peripheral vessels.

Organic nitrates and method for their preparation

The present invention relates to the use of 3-formyl-1,4-dihydropyridine derivatives as medicaments for the control of cardiovascular diseases, in particular of pathologically changed blood pressure and of cardiac insufficiency, new compounds and a process for their preparation.

Certain 3-formyl-1, 4-dihydropyridines and their pharmaceutical

Intermediate benzothiazolyl- and benzoxazolyl-aldehyde compounds

The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and intermediates thereof and to their use in medicaments, in particular in compositions having positively inotropic action.

3-phenyl-1,7-naphthyridine and cinnoline-5-carboxyaldehyde intermediates

Growing community of inventors

Wuppertal, Germany

Joachim Hutter