Roche Diagnostics Operations, Inc.

Roche Diabetes Care, Inc.

Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Other

Boehringer Mannehim Gmbh

Joachim Hoenes

Carina Horn

Hans-Peter Haar

Volker Zimmer

Hans List

Dieter Heindl

Uwe Kraemer

Wolfgang-Reinhold Knappe

Karl Miltner

Volker Unkrig

Claudia Gaessler-Dietsche

Herbert Harttig

Hans Wielinger

Rainer Schmuck

Rudolf Pachl

Christian Hoerauf

Guenther Schmelzeisen-Redeker

Holger Kotzan

Michael Keil

Thomas Weiss

Frank Deck

Michael Marquant

Wolfgang Petrich

Hans-Juergen Kuhr

Wilfried Schmid

Thomas Meier

Piet Herdewijn

Heino Eikmeier

Frederic Wehowski

Joerg Dreibholz

Zhixin Shao

Ewald Rieger

Christine Nortmeyer

Ortrud Quarder

Dirk Voelkel

Heinrich Fruhstorfer

Jürgen Spinke

Franz Wittmann

Jurgen Schaeffler

Herbert Von Der Eltz

Juergen Rasch-Menges

Irio Giuseppe Calasso

Christian Ringemann

Karl Werner

Bruno Robert Thoes

Paul Jansen

Reinhold Mischler

Bernd Hiller

Otto Gaa

Dan Mosoiu

Joerg Scherer

Werner Ruhl

Beate Koschorreck

Mihail-Onoriu Lungu

Peter Hess

Andreas Weller

Andreas Poredda

Maria Manser

Mihail Onoriu Lungu

Michael Marouant

Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

Portable diagnostic measurement device for determining analytical parameter of body fluid

The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.

Stabilization of dehydrogenases with stable coenzymes

Methods for detecting an analyte in a body fluid are described as well as devices and systems adapted for performing such methods. In embodiments of the method, a sample of body fluid is applied to a test element having at least one test field including at least one test material that is adapted to change at least one measurable property in the presence of the analyte. The test element further includes a capillary to guide the sample across said test field in a flow direction. The test element also includes first and second measurement locations offset from each other in the flow direction. The measurable property is measured in at least one first measurement location, providing at least one first measurement value, and it is measured in at least one second measurement location, providing at least one second measurement value. The analyte is detected by using an evaluation algorithm having at least two input variables, wherein at least one first input variable of the at least two input variables includes a difference between the first measurement value and the second measurement value, and at least one second input variable of the at least two input variables includes information relating to an analyte-induced change of the measurable property of the test material in at least part of the test field.

Method and device for generating a corrected value of an analyte concentration in a sample of a body fluid

Disclosed is a puncturing system for generating a puncture wound for obtaining a sample of a body fluid, comprising a press-on part to be pressed onto a body part in which a puncture wound is to be generated, a trigger, by the actuation of which a user can trigger a puncturing motion of a puncturing element after the press-on part is pressed on, and a testing facility for determining at least one test parameter on which a sample-obtaining probability depends. A securing facility is also provided that, in a locked state, locks the trigger such that no puncturing motion can be triggered, and, in a triggering state, releases the trigger such that a puncturing motion can be triggered by actuation thereof, whereby the securing facility is transitioned from the locked state to the triggering state by the testing facility when the test parameter determined by the testing facility meets defined minimum requirements. A signaling facility is also provided for signaling a transition of the securing facility to the triggering state and/or for signaling that the securing facility is in the triggering state. Also disclosed is a method for preparing a puncturing system for generating a puncture wound.

Puncturing system

The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.

Stable NAD/NADH derivatives

Portable diagnostic measurement device for determining at least one analytical parameter of a body fluid

A test instrument for analyzing body fluids such as blood or urine. The instrument includes a wound test tape which can be transported from a storage space into a waste space by advancing the tap. The test tape has a plurality of test sections to which body fluid can be applied at a receiving position and also includes a measuring unit for detecting a constituent of the body fluid on an active test section. In order to carry out auxiliary instrument functions, in addition to the test sections, the test tape has one or more functional sections which can be brought into a functional position by advancing the tape.

Method for analyzing body fluids

The invention also relates to compounds, which are useful for intra-molecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.

Compounds useful for FRET and methods related thereto

The invention relates to the field of integrated systems which comprise a test element and a lancet which can be firstly used to make a wound in a skin opening in order to collect a sample. The sample is subsequently directly taken up by the test element in the process of which it comes into contact with a reagent contained in the test element and results in an optically detectable change in a test field. The change in the test field is detected by means of an analytical unit which is optically contacted with the test field via at least one light-conducting element.

Integrated test element

Test device for analyzing body fluids

The invention relates to a lancet, which has a lancet tip at a front end and which on an upper face comprises a contact surface for placing a test element thereon and at least one channel for receiving a sample, wherein an upwardly open section of the channel runs in the contact surface. According to the invention, the channel has another upwardly open channel section which runs on the upper face of the lancet in or adjacent to a surface area that is lower than the contact surface, wherein the contact surface is arranged between the lancet tip and the lower surface area. The invention further relates to a system comprising such a lancet and a test element, and to a method for transferring a liquid sample from a channel of a lancet which is designed as a groove or slot to a test element.

Lancet

The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.

Fast reaction kinetics of enzymes having low activity in dry chemistry layers

The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.

Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH

Growing community of inventors

Zwingenberg, Germany

Joachim Hoenes