Technische Universitát Dresden

Technische Universitaet Dresden

Joachim Haupt

Yixin Zhang

Michael Schroeder

Petra Lennig

Joerg-Christian Heinrich

Jörg-Christian Heinrich

Sainitin Donakonda

The present invention relates to novel compounds as new chemical entities with thymine skeleton, these compounds for use as in medicine, especially in the treatment of carcinoma, HSP27-associated diseases and cystic fibrosis; and a pharmaceutical product containing at least one of these compounds. Finally, a method of production of that novel compounds is presented. General formula of these compounds is formula (I): 

Compounds with thymine skeleton for use in medicine

The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.

Thymine derivatives and quinazoline-dione derivatives for the inhibition of HSP27

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Bobritzsch-Hilbersdorf, Germany

Joachim Haupt