Sanofi

Sanofi-a Ventis Deutschland Gmbh

Joachim Graeser

Tobias Metzenthin

Adolf Heinz Linkies

Guenter Billen

Javier Manero

Kai Rossen

Volker Kraft

Richard Bicker

Gerhard Kretzschmar

Claus-Jürgen Maier

A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone. 

Process for the production of dronedarone intermediates

This disclosure relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof.

Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives

This invention relates to a novel process for obtaining a compound of formula I: wherein the values of R1, R2, and R3 and P are as described in the specification.

A process is described for preparing compounds of formula (I)where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CHgroups may be replaced by &#x2014;O&#x2014;. The compounds of the formula (I) are valuable intermediates in the synthesis of PPAR agonists.

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Frankfurt am Main, Germany

Joachim Graeser