Sterna Biologicals Gmbh & Co. Kg

Joachim Bille

Agnieszka Turowska

Jonas Renz

Chronic inflammation is an increasing medical problem area of high socioeconomic significance. The invention relates to a method and a kit for diagnosing a molecular phenotype of a patient suffering from an illness accompanied by chronic inflammation, and to a medicament for treating such a patient. To that end, the gene expression of GATA-3 and/or Tbet in a biological isolate of the patient is measured and used for association with a molecular phenotype of the illness.

Method for diagnosing a molecular phenotype of a patient suffering from an illness accompanied by chronic inflammation

The invention relates to GATA-3 inhibitors for use in the treatment of Th2-driven asthma, in particular to DNAzymes directed at GATA-3 for use in the treatment of a patient suffering from allergic asthma, wherein the patient is characterized by (i) a blood eosinophil count of 3% or more, particularly of 4% or more, more particularly of 5% or more; and/or (ii) blood eosinophil count of 350&#xd7;10/L or more, particularly of 450&#xd7;10/L or more; and/or (iii) fractional expiratory nitric oxide of 40 ppb or more.

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Reiskirchen, Germany

Joachim Bille