Rutgers, the State University of New Jersey

Massachusetts Institute of Technology

Other

Enzon, Inc.

Reva Medical, Inc.

Integra Lifesciences I, Ltd.

Joachim B Kohn

Durgadas Bolikal

Satish K Pulapura

Lioubov Kabalnova

Eric V Schmid

Joan Zeltinger

Stephen James Brocchini

Ernest G Baluca

Don K Brandom

Chun Li

Robert Samuel Langer

Stephen R Hanson

Donald K Brandom

Sanyog Manohar Pendharkar

Deborah M Schachter

Raman Bahulekar

Ramiro Rojas

John E Kemnitzer, Iii

Ken James

Varawut Tangpasuthadol

Chun Yu

David D Devore

Carmine P Iovine

Samuel Zalipsky

George L Brode

Isaac John Khan

Arthur Schwartz

Larisa Sheihet

Kristen S Labazzo

Aruna Nathan

Christelle M Lhommeau

Howard B Levene

James J Fiordeliso

Kimberly A Hooper

Jaap Schut

James E McGrath

Agnieszka Seyda

Nava Shpaisman

Robert R Dubin

Mindy Ezra Sadik

Atif J Khan

David J Riley

George J Poiani

Niraj Ramachandran

Jenny E Raynor

Carmine P Lovine

Arthur Schwarz

Steven M Niemi

Stephen Brochini

Basak Clements

Sanyong M Pendharkar

Julian Chesterman

Jarrod Cohen

Francesca D'Acunzo

Jared S Bushman

Brochini Stephen

Bo Qui

Sylvie I Ertel

Shuiyun Guan

Bozena Michniak

Prafulla Chandra

Priya Batheja

Chun Liz

Arthur L Schwartz

James G Fox

James E Mcgrath

Corinne Vebert-Nardin

Bo Qiu

David Devore

Mindy Ezra

Aaron F Pesnell

Kenneth James

Sanyog M Pendharkar

John E Kemnitzer

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Polymeric biomaterials derived from phenolic monomers and their medical uses

Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula 

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.

Inherently radiopaque polymeric products for embolotherapy

The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.

Biocompatible polymers for medical devices

A biocompatible nerve conduit for nerve re-generation, wherein a porous fiber tube is coated with a bioresorbable hydrogel, with the fibers being formed from a polymer that supports nerve regeneration by preferential adsorption of endogenous proteins and braided with pores in the range from 5 to 200 micrometers using a kink-resistant braiding pattern and the hydro gel coating material and thickness being selected to control the overall porosity, so that nutrients and oxygen can diffuse through said hydrogel coating but the infiltration of fibrous tissue through the coating is prevented.

Biocompatible implants for nerve re-generation and methods of use thereof

Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbability and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers. 

The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

Polymeric biomaterials derived from monomers comprising hydroxyacids and phenol compounds and their medical uses

The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogs, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

Disclosed are monomeric compounds which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radiopacity and are useful for medical device applications and controlled release therapeutic formulations.

Biocompatible iodinated diphenol monomers and polymers

Biodegradable, bioabsorbable cross-linked polymer tissue scaffolds for filling a void in human or animal soft tissue, such as a surgical or other wound, are disclosed. Drugs incorporated into the polymer backbone and/or loaded into the matrix are released directly to the target site. Additional non-toxic chemical constituents can be used to tune the hydrophilio hydrophobic and other physical properties of the cross-linked polymer tissue scaffolds, and incorporating brominated or iodinated constituents provides radio-opacity. The radio-opaque cross-linked polymer tissue scaffolds can assist in the targeting of radiation therapy.

Biocompatible polymer compositions for tissue void filling

Disclosed are monomeric compounds which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.

Growing community of inventors

Piscataway, NJ, United States of America

Joachim B Kohn