Vrije Universiteit Brussel

Vib Vzw

Universiteit Gent

Jo Van Ginderachter

Nick Devoogdt

Patrick De Baetselier

Geert Raes

Damya Laoui

Tony Lahoutte

Steve Schoonooghe

Kiavash Movahedi

Peter Vanlandschoot

Marleen Keyaerts

Catarina Xavier

Jiri Keirsse

Karine Breckpot

Quentin Lecocq

Benoît Stijlemans

Martin Guilliams

Jessica Bridoux

Ines Cabrito

Amanda Sparkes

Katrijn Broos

The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human Programmed Death Ligand-1 (huPDL1) and to applications of such polypeptides such as for use as a medicament or for use as diagnostic agent, for example as an immunotracer.

Human PD-L1-binding immunoglobulins

The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.

Immunoglobulin single variable domains directed against macrophage migration inhibitory factor

The present application relates to tumor-associated dendritic cell (TADC) preparations and their use in treatment of tumor metastasis.

Tumor-associated dendritic cell preparations and uses thereof

The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.

Targeting and in vivo imaging of tumor-associated macrophages

The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.

Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages

The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.

Growing community of inventors

Ninove, Belgium

Jo Van Ginderachter