Duke University

University of Florida Research Foundation, Incorporated

Korea Research Institute of Chemical Technology

Jiyong Hong

Hendrik Luesch

Philip Floyd Hughes

Pei Zhou

Mark DeWhirst

Dennis J Thiele

Timothy Haystead

Hyoungsu Kim

Amanda C Kasper

Eui Jung Moon

Yongho Park

Ceshea M Wooten

Bushu Dong

Alexander M Jaeger

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

Compositions and methods for the treatment of cancer

This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to translesion synthesis (TLS) pathway. More particularly, this disclosure relates to small molecule inhibitors of TLS, methods of inhibiting TLS pathway with these compounds, and methods of treating diseases related to the TLS pathway.

Compositions and methods for adjuvant cancer therapeutics

The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.

Macrocyclic compounds and methods of treatment

Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provided are pharmaceutical compositions comprising compounds according to Formula I. Also provided are methods of inhibiting HIF-1 in a cell, the methods comprising administering to the cell a compound according to Formula I.

Manassatin compounds and methods of making and using the same

The instant invention describes methods for producing macrocyclic compounds having antiproliferation activity, and useful in methods of treating disorders such as cancer, tumors and cell proliferation related disorders.

Methods of preparation of macrocyclic compounds

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Durham, NC, United States of America

Jiyong Hong