Henan Medinno Pharmaceutical Technology Co., Ltd.

Jixuan Zhang

Liang Lu

Saisai Zhao

Hai Huang

Longzheng Zhang

Jiaxin Chen

Xiaolong Wang

Junjie Zhu

Xinwei Liao

The present disclosure relates to a class of JAK inhibitor compounds and uses thereof. Specifically, the present disclosure discloses a compound represented by formula (G), isotopically labeled compound thereof, or optical isomer thereof, geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof. The present disclosure also relates to the application of the compounds in medicine.

Substituted pyrrolo[3,4-d]imidazoles as JAK inhibitors

The present disclosure relates to substituted pyrrollo[3,4-D]imidazoles as JAK inhibitor compounds and uses thereof. Specifically, the present disclosure discloses a compound represented by formula (I), optical isomer thereof, geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a metabolite thereof. The present disclosure also relates to the application of the compounds in the treatment of JAK-related diseases or disorders. 

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Zhengzhou, China

Jixuan Zhang