Life Technologies Corporation

Aat Bioquest, Inc.

Invitrogen Corporation

Molecular Probes, Inc.

Jixiang Liu

Zhenjun Diwu

Kyle R Gee

Wai-Yee Leung

Jolene Ann Bradford

Gayle Buller

Stephen T Yue

Richard P Haugland

Haitao Guo

Ruogu Peng

Qin Zhao

Iain Johnson

Thomas H Steinberg

Brian Patch

Yue Ge

Robert H Batchelor

Hee Chol Kang

Jinfang Liao

Zhen Luo

Pengfei Dong

Christopher Langsdorf

Peter Smalley

Wayne Forrest Patton

Joseph M Beechem

Vladimir Martin

Brian Agnew

Peter Aaron Emrys Smalley

Robert Batchelor

Fluorescent water soluble conjugated polymers including polycyclic aromatic comonomers are provided. The conjugated polymers can be linked to an acceptor fluorescent dye. The conjugated polymers find use in conjugates with biological substrates having applications in a variety of applications including methods of analyte detection.

Condensed polycyclic conjugated polymers and their use for biological detection

Styryl compounds useful for preparing biological detections probes, and the use of the Styryl compounds for the detection, discrimination and quantification of biological targets.

Styryl phenols, derivatives and their use in methods of analyte detection

Described herein are compounds, methods, and kits for long-term tracking of cell proliferation, differentiation, and/or function. The compounds of the present invention are novel cell-tracking reagents, efficiently excitable with a 405-nm violet laser, that provide bright fluorescence intensity, uniform cell staining, and good retention within cells as well as low toxicity toward cells.

7-hydroxycoumarin-based cell-tracking reagents

The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.

Violet laser excitable dyes and their method of use

The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.

Pyrenyloxysulfonic acid fluorescent agents

Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.

Carbofluorescein lactone ion indicators and their applications

The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.

Fluorinated resorufin compounds and their application

The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.

Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings

Actinomysin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided. The actinomysin-based near IR emitting compounds have the structure:  wherein R is H or NH; R, R, R, and Rare independently a moiety comprising 1-30 atoms selected from H, O, C, and N, wherein the atoms are in a linear, branched, or cyclic configuration; Rand/or Rcomprise a quaternary nitrogen atom; and Ris H, F, or Cl.

Modified actinomycin-based nucleic acid stains and methods of their use

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Eugene, OR, United States of America

Jixiang Liu